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Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica.
Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. Stack CM, et al. Among authors: seshaadri a. J Biol Chem. 2008 Apr 11;283(15):9896-908. doi: 10.1074/jbc.M708521200. Epub 2007 Dec 26. J Biol Chem. 2008. PMID: 18160404 Free PMC article.
RG7128 alone or in combination with pegylated interferon-α2a and ribavirin prevents hepatitis C virus (HCV) Replication and selection of resistant variants in HCV-infected patients.
Le Pogam S, Seshaadri A, Ewing A, Kang H, Kosaka A, Yan JM, Berrey M, Symonds B, De La Rosa A, Cammack N, Nájera I. Le Pogam S, et al. Among authors: seshaadri a. J Infect Dis. 2010 Nov 15;202(10):1510-9. doi: 10.1086/656774. Epub 2010 Oct 13. J Infect Dis. 2010. PMID: 20942646 Clinical Trial.