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2019 2
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Page 1
XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation.
Richart L, Picod-Chedotel ML, Wassef M, Macario M, Aflaki S, Salvador MA, Héry T, Dauphin A, Wicinski J, Chevrier V, Pastor S, Guittard G, Le Cam S, Kamhawi H, Castellano R, Guasch G, Charafe-Jauffret E, Heard E, Margueron R, Ginestier C. Richart L, et al. Among authors: aflaki s. Cell. 2022 Jun 9;185(12):2164-2183.e25. doi: 10.1016/j.cell.2022.04.034. Epub 2022 May 20. Cell. 2022. PMID: 35597241 Free article.
EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.
Ragazzini R, Pérez-Palacios R, Baymaz IH, Diop S, Ancelin K, Zielinski D, Michaud A, Givelet M, Borsos M, Aflaki S, Legoix P, Jansen PWTC, Servant N, Torres-Padilla ME, Bourc'his D, Fouchet P, Vermeulen M, Margueron R. Ragazzini R, et al. Among authors: aflaki s. Nat Commun. 2019 Aug 26;10(1):3858. doi: 10.1038/s41467-019-11800-x. Nat Commun. 2019. PMID: 31451685 Free PMC article.
Divergent local and systemic antitumor response in primary uveal melanomas.
Lucibello F, Lalanne AI, Le Gac AL, Soumare A, Aflaki S, Cyrta J, Dubreuil L, Mestdagh M, Salou M, Houy A, Ekwegbara C, Jamet C, Gardrat S, Le Ven A, Bernardeau K, Cassoux N, Matet A, Malaise D, Pierron G, Piperno-Neumann S, Stern MH, Rodrigues M, Lantz O. Lucibello F, et al. Among authors: aflaki s. J Exp Med. 2024 Jun 3;221(6):e20232094. doi: 10.1084/jem.20232094. Epub 2024 Apr 2. J Exp Med. 2024. PMID: 38563818
EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer.
Wassef M, Luscan A, Aflaki S, Zielinski D, Jansen PWTC, Baymaz HI, Battistella A, Kersouani C, Servant N, Wallace MR, Romero P, Kosmider O, Just PA, Hivelin M, Jacques S, Vincent-Salomon A, Vermeulen M, Vidaud M, Pasmant E, Margueron R. Wassef M, et al. Among authors: aflaki s. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6075-6080. doi: 10.1073/pnas.1814634116. Epub 2019 Mar 13. Proc Natl Acad Sci U S A. 2019. PMID: 30867289 Free PMC article.
EZH2 mutations in follicular lymphoma distort H3K27me3 profiles and alter transcriptional responses to PRC2 inhibition.
Romero P, Richart L, Aflaki S, Petitalot A, Burton M, Michaud A, Masliah-Planchon J, Kuhnowski F, Le Cam S, Baliñas-Gavira C, Méaudre C, Luscan A, Hamza A, Legoix P, Vincent-Salomon A, Wassef M, Holoch D, Margueron R. Romero P, et al. Among authors: aflaki s. Nat Commun. 2024 Apr 24;15(1):3452. doi: 10.1038/s41467-024-47701-x. Nat Commun. 2024. PMID: 38658543