Sfeir A - Search Results

1

Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance.

Tigano M, Vargas DC, Tremblay-Belzile S, Fu Y, Sfeir A. Tigano M, et al. Among authors: sfeir a. Nature. 2021 Mar;591(7850):477-481. doi: 10.1038/s41586-021-03269-w. Epub 2021 Feb 24. Nature. 2021. PMID: 33627873

2

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.

Mateos-Gomez PA, Gong F, Nair N, Miller KM, Lazzerini-Denchi E, Sfeir A. Mateos-Gomez PA, et al. Among authors: sfeir a. Nature. 2015 Feb 12;518(7538):254-7. doi: 10.1038/nature14157. Epub 2015 Feb 2. Nature. 2015. PMID: 25642960 Free PMC article.

3

Stop pulling my strings - what telomeres taught us about the DNA damage response.

Lazzerini-Denchi E, Sfeir A. Lazzerini-Denchi E, et al. Among authors: sfeir a. Nat Rev Mol Cell Biol. 2016 Jun;17(6):364-78. doi: 10.1038/nrm.2016.43. Epub 2016 May 11. Nat Rev Mol Cell Biol. 2016. PMID: 27165790 Free PMC article. Review.

4

Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion.

Phillips AF, Millet AR, Tigano M, Dubois SM, Crimmins H, Babin L, Charpentier M, Piganeau M, Brunet E, Sfeir A. Phillips AF, et al. Among authors: sfeir a. Mol Cell. 2017 Feb 2;65(3):527-538.e6. doi: 10.1016/j.molcel.2016.12.014. Epub 2017 Jan 19. Mol Cell. 2017. PMID: 28111015 Free article.

5

Single-molecule analysis of mtDNA replication with high resolution.

Tigano M, Phillips AF, Sfeir A. Tigano M, et al. Among authors: sfeir a. Methods Cell Biol. 2020;155:401-414. doi: 10.1016/bs.mcb.2019.10.005. Epub 2019 Nov 20. Methods Cell Biol. 2020. PMID: 32183970

6

Safeguarding mitochondrial genomes in higher eukaryotes.

Fu Y, Tigano M, Sfeir A. Fu Y, et al. Among authors: sfeir a. Nat Struct Mol Biol. 2020 Aug;27(8):687-695. doi: 10.1038/s41594-020-0474-9. Epub 2020 Aug 6. Nat Struct Mol Biol. 2020. PMID: 32764737 Review.

7

In Vivo Analysis of mtDNA Replication at the Single Molecule Level and with High Resolution.

Tigano M, Phillips AF, Sfeir A. Tigano M, et al. Among authors: sfeir a. Methods Mol Biol. 2021;2192:21-34. doi: 10.1007/978-1-0716-0834-0_2. Methods Mol Biol. 2021. PMID: 33230762

8

Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis.

Fu Y, Sacco O, DeBitetto E, Kanshin E, Ueberheide B, Sfeir A. Fu Y, et al. Among authors: sfeir a. Mol Cell. 2023 Oct 19;83(20):3740-3753.e9. doi: 10.1016/j.molcel.2023.09.026. Epub 2023 Oct 12. Mol Cell. 2023. PMID: 37832546

9

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.

Mateos-Gomez PA, Kent T, Deng SK, McDevitt S, Kashkina E, Hoang TM, Pomerantz RT, Sfeir A. Mateos-Gomez PA, et al. Among authors: sfeir a. Nat Struct Mol Biol. 2017 Dec;24(12):1116-1123. doi: 10.1038/nsmb.3494. Epub 2017 Oct 23. Nat Struct Mol Biol. 2017. PMID: 29058711 Free PMC article.

10

DNA polymerase theta (Polθ) - an error-prone polymerase necessary for genome stability.

Brambati A, Barry RM, Sfeir A. Brambati A, et al. Among authors: sfeir a. Curr Opin Genet Dev. 2020 Feb;60:119-126. doi: 10.1016/j.gde.2020.02.017. Epub 2020 Apr 14. Curr Opin Genet Dev. 2020. PMID: 32302896 Free PMC article. Review.

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