Sharp SY - Search Results

1

Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma.

Gaspar N, Sharp SY, Eccles SA, Gowan S, Popov S, Jones C, Pearson A, Vassal G, Workman P. Gaspar N, et al. Among authors: sharp sy. Mol Cancer Ther. 2010 May;9(5):1219-33. doi: 10.1158/1535-7163.MCT-09-0683. Mol Cancer Ther. 2010. PMID: 20457619 Free PMC article.

2

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90.

Kelland LR, Sharp SY, Rogers PM, Myers TG, Workman P. Kelland LR, et al. Among authors: sharp sy. J Natl Cancer Inst. 1999 Nov 17;91(22):1940-9. doi: 10.1093/jnci/91.22.1940. J Natl Cancer Inst. 1999. PMID: 10564678

3

Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.

Sharp SY, Kelland LR, Valenti MR, Brunton LA, Hobbs S, Workman P. Sharp SY, et al. Mol Pharmacol. 2000 Nov;58(5):1146-55. doi: 10.1124/mol.58.5.1146. Mol Pharmacol. 2000. PMID: 11040064

4

Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.

Wright L, Barril X, Dymock B, Sheridan L, Surgenor A, Beswick M, Drysdale M, Collier A, Massey A, Davies N, Fink A, Fromont C, Aherne W, Boxall K, Sharp S, Workman P, Hubbard RE. Wright L, et al. Chem Biol. 2004 Jun;11(6):775-85. doi: 10.1016/j.chembiol.2004.03.033. Chem Biol. 2004. PMID: 15217611

5

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.

Cheung KM, Matthews TP, James K, Rowlands MG, Boxall KJ, Sharp SY, Maloney A, Roe SM, Prodromou C, Pearl LH, Aherne GW, McDonald E, Workman P. Cheung KM, et al. Among authors: sharp sy. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3338-43. doi: 10.1016/j.bmcl.2005.05.046. Bioorg Med Chem Lett. 2005. PMID: 15955698

6

Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90.

Hardcastle A, Boxall K, Richards J, Tomlin P, Sharp S, Clarke P, Workman P, Aherne W. Hardcastle A, et al. Assay Drug Dev Technol. 2005 Jun;3(3):273-85. doi: 10.1089/adt.2005.3.273. Assay Drug Dev Technol. 2005. PMID: 15971989

7

Inhibitors of the HSP90 molecular chaperone: current status.

Sharp S, Workman P. Sharp S, et al. Adv Cancer Res. 2006;95:323-48. doi: 10.1016/S0065-230X(06)95009-X. Adv Cancer Res. 2006. PMID: 16860662 Review.

8

Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.

Proisy N, Sharp SY, Boxall K, Connelly S, Roe SM, Prodromou C, Slawin AM, Pearl LH, Workman P, Moody CJ. Proisy N, et al. Among authors: sharp sy. Chem Biol. 2006 Nov;13(11):1203-15. doi: 10.1016/j.chembiol.2006.09.015. Chem Biol. 2006. PMID: 17114002

9

Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin.

McErlean CS, Proisy N, Davis CJ, Boland NA, Sharp SY, Boxall K, Slawin AM, Workman P, Moody CJ. McErlean CS, et al. Among authors: sharp sy. Org Biomol Chem. 2007 Feb 7;5(3):531-46. doi: 10.1039/b615378j. Epub 2007 Jan 4. Org Biomol Chem. 2007. PMID: 17252137

10

In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.

Sharp SY, Boxall K, Rowlands M, Prodromou C, Roe SM, Maloney A, Powers M, Clarke PA, Box G, Sanderson S, Patterson L, Matthews TP, Cheung KM, Ball K, Hayes A, Raynaud F, Marais R, Pearl L, Eccles S, Aherne W, McDonald E, Workman P. Sharp SY, et al. Cancer Res. 2007 Mar 1;67(5):2206-16. doi: 10.1158/0008-5472.CAN-06-3473. Cancer Res. 2007. PMID: 17332351 Free article.

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