Shaw RJ - Search Results

1

Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice.

Shaw RJ, Cantley LC. Shaw RJ, et al. F1000 Biol Rep. 2012;4:2. doi: 10.3410/B4-2. Epub 2012 Jan 3. F1000 Biol Rep. 2012. PMID: 22242042 Free PMC article.

2

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.

Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, Bozzuto CD, Ooi D, Cantley LC, Yuan J. Karuman P, et al. Mol Cell. 2001 Jun;7(6):1307-19. doi: 10.1016/s1097-2765(01)00258-1. Mol Cell. 2001. PMID: 11430832 Free article.

3

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. Shaw RJ, et al. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. doi: 10.1073/pnas.0308061100. Epub 2004 Feb 25. Proc Natl Acad Sci U S A. 2004. PMID: 14985505 Free PMC article.

4

The LKB1 tumor suppressor negatively regulates mTOR signaling.

Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. Shaw RJ, et al. Cancer Cell. 2004 Jul;6(1):91-9. doi: 10.1016/j.ccr.2004.06.007. Cancer Cell. 2004. PMID: 15261145 Free article.

5

DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.

Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD. Fernandes N, et al. Among authors: shaw rj. J Biol Chem. 2005 Apr 15;280(15):15158-64. doi: 10.1074/jbc.M412065200. Epub 2005 Feb 15. J Biol Chem. 2005. PMID: 15713674 Free article.

6

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. Shaw RJ, et al. Science. 2005 Dec 9;310(5754):1642-6. doi: 10.1126/science.1120781. Epub 2005 Nov 24. Science. 2005. PMID: 16308421 Free PMC article.

7

Ras, PI(3)K and mTOR signalling controls tumour cell growth.

Shaw RJ, Cantley LC. Shaw RJ, et al. Nature. 2006 May 25;441(7092):424-30. doi: 10.1038/nature04869. Nature. 2006. PMID: 16724053 Review.

8

Cell biology. Ancient sensor for ancient drug.

Shaw RJ, Cantley LC. Shaw RJ, et al. Science. 2012 May 18;336(6083):813-4. doi: 10.1126/science.1223140. Science. 2012. PMID: 22605741 No abstract available.

9

Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer.

Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, Driggers EM, Zhang J, Bailey ST, Sharpless NE, Hayes DN, Patel NM, Janne PA, Bardeesy N, Engelman JA, Manning BD, Shaw RJ, Asara JM, Scully R, Kimmelman A, Byers LA, Gibbons DL, Wistuba II, Heymach JV, Kwiatkowski DJ, Kim WY, Kung AL, Gray NS, Root DE, Cantley LC, Wong KK. Liu Y, et al. Among authors: shaw rj. Cancer Discov. 2013 Aug;3(8):870-9. doi: 10.1158/2159-8290.CD-13-0015. Epub 2013 May 28. Cancer Discov. 2013. PMID: 23715154 Free PMC article.

10

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks.

Stein BD, Calzolari D, Hellberg K, Hu YS, He L, Hung CM, Toyama EQ, Ross DS, Lillemeier BF, Cantley LC, Yates JR 3rd, Shaw RJ. Stein BD, et al. Among authors: shaw rj. Cell Rep. 2019 Dec 3;29(10):3331-3348.e7. doi: 10.1016/j.celrep.2019.10.117. Cell Rep. 2019. PMID: 31801093 Free PMC article.

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