Shearman MS - Search Results

1

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase.

Nunan J, Shearman MS, Checler F, Cappai R, Evin G, Beyreuther K, Masters CL, Small DH. Nunan J, et al. Among authors: shearman ms. Eur J Biochem. 2001 Oct;268(20):5329-36. doi: 10.1046/j.0014-2956.2001.02465.x. Eur J Biochem. 2001. PMID: 11606195 Free article.

2

The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.

Lichtenthaler SF, Beher D, Grimm HS, Wang R, Shearman MS, Masters CL, Beyreuther K. Lichtenthaler SF, et al. Among authors: shearman ms. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1365-70. doi: 10.1073/pnas.032395699. Epub 2002 Jan 22. Proc Natl Acad Sci U S A. 2002. PMID: 11805291 Free PMC article.

3

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

Beher D, Fricker M, Nadin A, Clarke EE, Wrigley JD, Li YM, Culvenor JG, Masters CL, Harrison T, Shearman MS. Beher D, et al. Among authors: shearman ms. Biochemistry. 2003 Jul 15;42(27):8133-42. doi: 10.1021/bi034045z. Biochemistry. 2003. PMID: 12846562

4

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology.

Beher D, Wrigley JD, Nadin A, Evin G, Masters CL, Harrison T, Castro JL, Shearman MS. Beher D, et al. Among authors: shearman ms. J Biol Chem. 2001 Nov 30;276(48):45394-402. doi: 10.1074/jbc.M103075200. Epub 2001 Sep 26. J Biol Chem. 2001. PMID: 11574530 Free article.

5

gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.

Grimm HS, Beher D, Lichtenthaler SF, Shearman MS, Beyreuther K, Hartmann T. Grimm HS, et al. Among authors: shearman ms. J Biol Chem. 2003 Apr 11;278(15):13077-85. doi: 10.1074/jbc.M210380200. Epub 2003 Jan 29. J Biol Chem. 2003. PMID: 12556458 Free article.

6

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity.

Shearman MS, Beher D, Clarke EE, Lewis HD, Harrison T, Hunt P, Nadin A, Smith AL, Stevenson G, Castro JL. Shearman MS, et al. Biochemistry. 2000 Aug 1;39(30):8698-704. doi: 10.1021/bi0005456. Biochemistry. 2000. PMID: 10913280

7

Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.

Lewis HD, Pérez Revuelta BI, Nadin A, Neduvelil JG, Harrison T, Pollack SJ, Shearman MS. Lewis HD, et al. Among authors: shearman ms. Biochemistry. 2003 Jun 24;42(24):7580-6. doi: 10.1021/bi034310g. Biochemistry. 2003. PMID: 12809514

8

Gamma-secretase inhibition.

Beher D, Shearman MS. Beher D, et al. Among authors: shearman ms. Biochem Soc Trans. 2002 Aug;30(4):534-7. doi: 10.1042/bst0300534. Biochem Soc Trans. 2002. PMID: 12196131 Review.

9

gamma-Secretase: characterization and implication for Alzheimer disease therapy.

Xu M, Lai MT, Huang Q, DiMuzio-Mower J, Castro JL, Harrison T, Nadin A, Neduvelil JG, Shearman MS, Shafer JA, Gardell SJ, Li YM. Xu M, et al. Among authors: shearman ms. Neurobiol Aging. 2002 Nov-Dec;23(6):1023-30. doi: 10.1016/s0197-4580(02)00126-4. Neurobiol Aging. 2002. PMID: 12470798

10

Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.

Beher D, Wrigley JD, Owens AP, Shearman MS. Beher D, et al. Among authors: shearman ms. J Neurochem. 2002 Aug;82(3):563-75. doi: 10.1046/j.1471-4159.2002.00985.x. J Neurochem. 2002. PMID: 12153480 Free article.

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