Shen J - Search Results

1

Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2.

Dhaliwal J, Kannangara TS, Vaculik M, Xue Y, Kumar KL, Maione A, Béïque JC, Shen J, Lagace DC. Dhaliwal J, et al. Among authors: shen j. Sci Rep. 2018 Dec 18;8(1):17931. doi: 10.1038/s41598-018-36363-7. Sci Rep. 2018. PMID: 30560948 Free PMC article.

2

Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease.

Beglopoulos V, Shen J. Beglopoulos V, et al. Among authors: shen j. Trends Pharmacol Sci. 2006 Jan;27(1):33-40. doi: 10.1016/j.tips.2005.11.010. Epub 2005 Dec 7. Trends Pharmacol Sci. 2006. PMID: 16337694 Review.

3

Hippocampal spatial memory impairments caused by the familial Alzheimer's disease-linked presenilin 1 M146V mutation.

Sun X, Beglopoulos V, Mattson MP, Shen J. Sun X, et al. Among authors: shen j. Neurodegener Dis. 2005;2(1):6-15. doi: 10.1159/000086426. Neurodegener Dis. 2005. PMID: 16908998

4

A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.

Heilig EA, Xia W, Shen J, Kelleher RJ 3rd. Heilig EA, et al. Among authors: shen j. J Biol Chem. 2010 Jul 16;285(29):22350-9. doi: 10.1074/jbc.M110.116962. Epub 2010 May 11. J Biol Chem. 2010. PMID: 20460383 Free PMC article.

5

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

Wu B, Yamaguchi H, Lai FA, Shen J. Wu B, et al. Among authors: shen j. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15091-6. doi: 10.1073/pnas.1304171110. Epub 2013 Aug 5. Proc Natl Acad Sci U S A. 2013. PMID: 23918386 Free PMC article.

6

Function and dysfunction of presenilin.

Shen J. Shen J. Neurodegener Dis. 2014;13(2-3):61-3. doi: 10.1159/000354971. Epub 2013 Oct 2. Neurodegener Dis. 2014. PMID: 24107444 Free PMC article. Review.

7

Synaptic function of nicastrin in hippocampal neurons.

Lee SH, Sharma M, Südhof TC, Shen J. Lee SH, et al. Among authors: shen j. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8973-8. doi: 10.1073/pnas.1408554111. Epub 2014 Jun 2. Proc Natl Acad Sci U S A. 2014. PMID: 24889619 Free PMC article.

8

Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex.

Watanabe H, Iqbal M, Zheng J, Wines-Samuelson M, Shen J. Watanabe H, et al. Among authors: shen j. J Neurosci. 2014 Nov 26;34(48):15912-22. doi: 10.1523/JNEUROSCI.3261-14.2014. J Neurosci. 2014. PMID: 25429133 Free PMC article.

9

Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.

Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ 3rd. Xia D, et al. Among authors: shen j. Neuron. 2015 Mar 4;85(5):967-81. doi: 10.1016/j.neuron.2015.02.010. Neuron. 2015. PMID: 25741723 Free PMC article.

10

Loss of Aβ43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain.

Xia D, Kelleher RJ 3rd, Shen J. Xia D, et al. Among authors: shen j. Neuron. 2016 Apr 20;90(2):417-22. doi: 10.1016/j.neuron.2016.03.009. Neuron. 2016. PMID: 27100200 Free PMC article.

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