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Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice.
Wohleb ES, Fenn AM, Pacenta AM, Powell ND, Sheridan JF, Godbout JP. Wohleb ES, et al. Among authors: sheridan jf. Psychoneuroendocrinology. 2012 Sep;37(9):1491-505. doi: 10.1016/j.psyneuen.2012.02.003. Epub 2012 Mar 2. Psychoneuroendocrinology. 2012. PMID: 22386198 Free PMC article.
Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain.
Sawicki CM, McKim DB, Wohleb ES, Jarrett BL, Reader BF, Norden DM, Godbout JP, Sheridan JF. Sawicki CM, et al. Among authors: sheridan jf. Neuroscience. 2015 Aug 27;302:151-64. doi: 10.1016/j.neuroscience.2014.10.004. Epub 2014 Oct 14. Neuroscience. 2015. PMID: 25445193 Free PMC article.
219 results