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Notch signaling is an important regulator of type 2 immunity.
Tu L, Fang TC, Artis D, Shestova O, Pross SE, Maillard I, Pear WS. Tu L, et al. Among authors: shestova o. J Exp Med. 2005 Oct 17;202(8):1037-42. doi: 10.1084/jem.20050923. J Exp Med. 2005. PMID: 16230473 Free PMC article.
Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.
Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, Rodriguez CG, Maillard I, Tobias JW, Valk P, Carroll M, Aster JC, Delwel R, Pear WS. Keeshan K, et al. Among authors: shestova o. Cancer Cell. 2006 Nov;10(5):401-11. doi: 10.1016/j.ccr.2006.09.012. Cancer Cell. 2006. PMID: 17097562 Free PMC article.
The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.
Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, Epstein JA, Speck N, Bigas A, Pear WS. Gerhardt DM, et al. Among authors: shestova o. Genes Dev. 2014 Mar 15;28(6):576-93. doi: 10.1101/gad.227496.113. Genes Dev. 2014. PMID: 24637115 Free PMC article.
Notch dimerization is required for leukemogenesis and T-cell development.
Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS. Liu H, et al. Among authors: shestova o. Genes Dev. 2010 Nov 1;24(21):2395-407. doi: 10.1101/gad.1975210. Epub 2010 Oct 8. Genes Dev. 2010. PMID: 20935071 Free PMC article.
46 results