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2-Phenoxy-3, 4'-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization.
Lv G, Shi Q, Zhang T, Li J, Kalashova J, Long Y, Sun Y, Li C, Choudhry N, Li H, Yang C, Zhou X, Reddy MC, Anantoju KK, Jupelli R, Zhang S, Zhang J, Allen T, Liu H, Nimishetti N, Yang D. Lv G, et al. Among authors: shi q. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114904. doi: 10.1016/j.ejmech.2022.114904. Epub 2022 Nov 8. Eur J Med Chem. 2023. PMID: 36413818
Integrating a phenotypic screening with a structural simplification strategy to identify 4-phenoxy-quinoline derivatives to potently disrupt the mitotic localization of Aurora kinase B.
Lv G, Shi Q, Zhang T, Li J, Long Y, Zhang W, Choudhry N, Yang K, Li H, Kalashova J, Yang C, Zhou X, Reddy MC, Anantoju KK, Zhang S, Zhang J, Allen TD, Liu H, Nimishetti N, Yang D. Lv G, et al. Among authors: shi q. Bioorg Med Chem. 2023 Feb 15;80:117173. doi: 10.1016/j.bmc.2023.117173. Epub 2023 Jan 16. Bioorg Med Chem. 2023. PMID: 36696874
7,911 results