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Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids.
Han SI, Nakakuki M, Nakagawa Y, Wang Y, Araki M, Yamamoto Y, Tokiwa H, Takeda H, Mizunoe Y, Motomura K, Ohno H, Kainoh K, Murayama Y, Aita Y, Takeuchi Y, Osaki Y, Miyamoto T, Sekiya M, Matsuzaka T, Yahagi N, Sone H, Daitoku H, Sato R, Kawano H, Shimano H. Han SI, et al. Among authors: shimano h. PNAS Nexus. 2023 Nov 8;2(11):pgad351. doi: 10.1093/pnasnexus/pgad351. eCollection 2023 Nov. PNAS Nexus. 2023. PMID: 37954160 Free PMC article.
A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.
Yahagi N, Shimano H, Hasty AH, Amemiya-Kudo M, Okazaki H, Tamura Y, Iizuka Y, Shionoiri F, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N. Yahagi N, et al. Among authors: shimano h. J Biol Chem. 1999 Dec 10;274(50):35840-4. doi: 10.1074/jbc.274.50.35840. J Biol Chem. 1999. PMID: 10585468 Free article.
Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene.
Amemiya-Kudo M, Shimano H, Yoshikawa T, Yahagi N, Hasty AH, Okazaki H, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N. Amemiya-Kudo M, et al. Among authors: shimano h. J Biol Chem. 2000 Oct 6;275(40):31078-85. doi: 10.1074/jbc.M005353200. J Biol Chem. 2000. PMID: 10918064 Free article.
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter.
Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N. Yoshikawa T, et al. Among authors: shimano h. Mol Cell Biol. 2001 May;21(9):2991-3000. doi: 10.1128/MCB.21.9.2991-3000.2001. Mol Cell Biol. 2001. PMID: 11287605 Free PMC article.
[Gene therapy for hyperlipoproteinemia].
Yahagi N, Ishibashi S, Shimano H. Yahagi N, et al. Among authors: shimano h. Nihon Rinsho. 2001 Mar;59 Suppl 3:715-21. Nihon Rinsho. 2001. PMID: 11347160 Review. Japanese. No abstract available.
Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor.
Hasty AH, Shimano H, Osuga J, Namatame I, Takahashi A, Yahagi N, Perrey S, Iizuka Y, Tamura Y, Amemiya-Kudo M, Yoshikawa T, Okazaki H, Ohashi K, Harada K, Matsuzaka T, Sone H, Gotoda T, Nagai R, Ishibashi S, Yamada N. Hasty AH, et al. Among authors: shimano h. J Biol Chem. 2001 Oct 5;276(40):37402-8. doi: 10.1074/jbc.M010176200. Epub 2001 Jul 9. J Biol Chem. 2001. PMID: 11445560 Free article.
Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements.
Yoshikawa T, Shimano H, Yahagi N, Ide T, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Takahashi A, Sone H, Osuga Ji J, Gotoda T, Ishibashi S, Yamada N. Yoshikawa T, et al. Among authors: shimano h. J Biol Chem. 2002 Jan 18;277(3):1705-11. doi: 10.1074/jbc.M105711200. Epub 2001 Nov 2. J Biol Chem. 2002. PMID: 11694526 Free article.
Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status.
Sone H, Shimano H, Sakakura Y, Inoue N, Amemiya-Kudo M, Yahagi N, Osawa M, Suzuki H, Yokoo T, Takahashi A, Iida K, Toyoshima H, Iwama A, Yamada N. Sone H, et al. Among authors: shimano h. Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E222-30. doi: 10.1152/ajpendo.00189.2001. Am J Physiol Endocrinol Metab. 2002. PMID: 11739104 Free article.
434 results