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Page 1
Selective orexin receptor antagonists.
Lebold TP, Bonaventure P, Shireman BT. Lebold TP, et al. Among authors: shireman bt. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4761-9. doi: 10.1016/j.bmcl.2013.06.057. Epub 2013 Jul 4. Bioorg Med Chem Lett. 2013. PMID: 23891187 Review.
2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists.
Shireman BT, Dvorak CA, Rudolph DA, Bonaventure P, Nepomuceno D, Dvorak L, Miller KL, Lovenberg TW, Carruthers NI. Shireman BT, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2103-8. doi: 10.1016/j.bmcl.2008.01.090. Epub 2008 Jan 30. Bioorg Med Chem Lett. 2008. PMID: 18282705
A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects.
Bonaventure P, Yun S, Johnson PL, Shekhar A, Fitz SD, Shireman BT, Lebold TP, Nepomuceno D, Lord B, Wennerholm M, Shelton J, Carruthers N, Lovenberg T, Dugovic C. Bonaventure P, et al. Among authors: shireman bt. J Pharmacol Exp Ther. 2015 Mar;352(3):590-601. doi: 10.1124/jpet.114.220392. Epub 2015 Jan 12. J Pharmacol Exp Ther. 2015. PMID: 25583879 Free PMC article.
Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate.
Letavic MA, Bonaventure P, Carruthers NI, Dugovic C, Koudriakova T, Lord B, Lovenberg TW, Ly KS, Mani NS, Nepomuceno D, Pippel DJ, Rizzolio M, Shelton JE, Shah CR, Shireman BT, Young LK, Yun S. Letavic MA, et al. Among authors: shireman bt. J Med Chem. 2015 Jul 23;58(14):5620-36. doi: 10.1021/acs.jmedchem.5b00742. Epub 2015 Jul 8. J Med Chem. 2015. PMID: 26087021
Substituted 5,6-(Dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-methanones as P2X7 Antagonists.
Ziff J, Rudolph DA, Stenne B, Koudriakova T, Lord B, Bonaventure P, Lovenberg TW, Carruthers NI, Bhattacharya A, Letavic MA, Shireman BT. Ziff J, et al. Among authors: shireman bt. ACS Chem Neurosci. 2016 Apr 20;7(4):498-504. doi: 10.1021/acschemneuro.5b00304. Epub 2016 Jan 19. ACS Chem Neurosci. 2016. PMID: 26754558
20 results