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Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells.
Estrov Z, Shishodia S, Faderl S, Harris D, Van Q, Kantarjian HM, Talpaz M, Aggarwal BB. Estrov Z, et al. Among authors: shishodia s. Blood. 2003 Aug 1;102(3):987-95. doi: 10.1182/blood-2002-11-3550. Epub 2003 Apr 10. Blood. 2003. PMID: 12689943 Free article.
Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis.
Bharti AC, Shishodia S, Reuben JM, Weber D, Alexanian R, Raj-Vadhan S, Estrov Z, Talpaz M, Aggarwal BB. Bharti AC, et al. Among authors: shishodia s. Blood. 2004 Apr 15;103(8):3175-84. doi: 10.1182/blood-2003-06-2151. Epub 2003 Dec 18. Blood. 2004. PMID: 15070700 Free article.
86 results