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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2010 2
2011 1
2012 5
2013 9
2014 6
2015 5
2016 9
2018 2
2019 1
2020 6
2021 10
2022 5
2023 1
2024 0

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54 results

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Page 1
RAS-targeted therapies: is the undruggable drugged?
Moore AR, Rosenberg SC, McCormick F, Malek S. Moore AR, et al. Among authors: malek s. Nat Rev Drug Discov. 2020 Aug;19(8):533-552. doi: 10.1038/s41573-020-0068-6. Epub 2020 Jun 11. Nat Rev Drug Discov. 2020. PMID: 32528145 Free PMC article. Review.
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy.
Song KW, Edgar KA, Hanan EJ, Hafner M, Oeh J, Merchant M, Sampath D, Nannini MA, Hong R, Phu L, Forrest WF, Stawiski E, Schmidt S, Endres N, Guan J, Wallin JJ, Cheong J, Plise EG, Lewis Phillips GD, Salphati L, Heffron TP, Olivero AG, Malek S, Staben ST, Kirkpatrick DS, Dey A, Friedman LS. Song KW, et al. Among authors: malek s. Cancer Discov. 2022 Jan;12(1):204-219. doi: 10.1158/2159-8290.CD-21-0072. Epub 2021 Sep 20. Cancer Discov. 2022. PMID: 34544753 Free PMC article.
RAS-targeted therapies.
Moore AR, Rosenberg SC, McCormick F, Malek S. Moore AR, et al. Among authors: malek s. Nat Rev Drug Discov. 2021 May 14. doi: 10.1038/s41573-021-00220-6. Online ahead of print. Nat Rev Drug Discov. 2021. PMID: 33990767 No abstract available.
Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation.
Rosenberg SC, Shanahan F, Yamazoe S, Kschonsak M, Zeng YJ, Lee J, Plise E, Yen I, Rose CM, Quinn JG, Gazzard LJ, Walters BT, Kirkpatrick DS, Staben ST, Foster SA, Malek S. Rosenberg SC, et al. Among authors: malek s. Cell Chem Biol. 2023 Feb 8:S2451-9456(23)00030-2. doi: 10.1016/j.chembiol.2023.01.007. Online ahead of print. Cell Chem Biol. 2023. PMID: 36773603 Free article.
Targeting the MAPK Pathway in RAS Mutant Cancers.
Hymowitz SG, Malek S. Hymowitz SG, et al. Among authors: malek s. Cold Spring Harb Perspect Med. 2018 Nov 1;8(11):a031492. doi: 10.1101/cshperspect.a031492. Cold Spring Harb Perspect Med. 2018. PMID: 29440321 Free PMC article. Review.
ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma.
Yen I, Shanahan F, Lee J, Hong YS, Shin SJ, Moore AR, Sudhamsu J, Chang MT, Bae I, Dela Cruz D, Hunsaker T, Klijn C, Liau NPD, Lin E, Martin SE, Modrusan Z, Piskol R, Segal E, Venkatanarayan A, Ye X, Yin J, Zhang L, Kim JS, Lim HS, Kim KP, Kim YJ, Han HS, Lee SJ, Kim ST, Jung M, Hong YH, Noh YS, Choi M, Han O, Nowicka M, Srinivasan S, Yan Y, Kim TW, Malek S. Yen I, et al. Among authors: malek s. Nature. 2021 Jun;594(7863):418-423. doi: 10.1038/s41586-021-03515-1. Epub 2021 May 5. Nature. 2021. PMID: 33953400 Clinical Trial.
CRAF dimerization with ARAF regulates KRAS-driven tumor growth.
Venkatanarayan A, Liang J, Yen I, Shanahan F, Haley B, Phu L, Verschueren E, Hinkle TB, Kan D, Segal E, Long JE, Lima T, Liau NPD, Sudhamsu J, Li J, Klijn C, Piskol R, Junttila MR, Shaw AS, Merchant M, Chang MT, Kirkpatrick DS, Malek S. Venkatanarayan A, et al. Among authors: malek s. Cell Rep. 2022 Feb 8;38(6):110351. doi: 10.1016/j.celrep.2022.110351. Cell Rep. 2022. PMID: 35139374 Free article.
The promise and peril of KRAS G12C inhibitors.
Moore AR, Malek S. Moore AR, et al. Among authors: malek s. Cancer Cell. 2021 Aug 9;39(8):1059-1061. doi: 10.1016/j.ccell.2021.07.011. Cancer Cell. 2021. PMID: 34375610 Free article.
54 results