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Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status.
Bone Res. 2023 Nov 24;11(1):62. doi: 10.1038/s41413-023-00297-2.
Bone Res. 2023.
PMID: 38001111
Free PMC article.
Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics.
Jayapalan S, Nandy A, Rendina-Ruedy E.
Jayapalan S, et al.
J Vis Exp. 2022 Mar 1;(181):10.3791/63142. doi: 10.3791/63142.
J Vis Exp. 2022.
PMID: 35311813
Free PMC article.
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Untargeted metabolomics in primary murine bone marrow stromal cells reveals distinct profile throughout osteoblast differentiation.
Misra BB, Jayapalan S, Richards AK, Helderman RCM, Rendina-Ruedy E.
Misra BB, et al. Among authors: jayapalan s.
Metabolomics. 2021 Sep 18;17(10):86. doi: 10.1007/s11306-021-01829-9.
Metabolomics. 2021.
PMID: 34537901
Free PMC article.
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Loss of function of lysosomal acid lipase (LAL) profoundly impacts osteoblastogenesis and increases fracture risk in humans.
Helderman RC, Whitney DG, Duta-Mare M, Akhmetshina A, Vujic N, Jayapalan S, Nyman JS, Misra BB, Rosen CJ, Czech MP, Kratky D, Rendina-Ruedy E.
Helderman RC, et al. Among authors: jayapalan s.
Bone. 2021 Jul;148:115946. doi: 10.1016/j.bone.2021.115946. Epub 2021 Apr 7.
Bone. 2021.
PMID: 33838322
Free PMC article.
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