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Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging.
Mogilenko DA, Shpynov O, Andhey PS, Arthur L, Swain A, Esaulova E, Brioschi S, Shchukina I, Kerndl M, Bambouskova M, Yao Z, Laha A, Zaitsev K, Burdess S, Gillfilan S, Stewart SA, Colonna M, Artyomov MN. Mogilenko DA, et al. Among authors: shpynov o. Immunity. 2021 Jan 12;54(1):99-115.e12. doi: 10.1016/j.immuni.2020.11.005. Epub 2020 Dec 2. Immunity. 2021. PMID: 33271118 Free article.
Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release.
Tufan T, Comertpay G, Villani A, Nelson GM, Terekhova M, Kelley S, Zakharov P, Ellison RM, Shpynov O, Raymond M, Sun J, Chen Y, Bockelmann E, Stremska M, Peterson LW, Boeckaerts L, Goldman SR, Etchegaray JI, Artyomov MN, Peri F, Ravichandran KS. Tufan T, et al. Among authors: shpynov o. Nature. 2024 Apr;628(8007):408-415. doi: 10.1038/s41586-024-07172-y. Epub 2024 Mar 13. Nature. 2024. PMID: 38480883
Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome.
Shchukina I, Bagaitkar J, Shpynov O, Loginicheva E, Porter S, Mogilenko DA, Wolin E, Collins P, Demidov G, Artomov M, Zaitsev K, Sidorov S, Camell C, Bambouskova M, Arthur L, Swain A, Panteleeva A, Dievskii A, Kurbatsky E, Tsurinov P, Chernyatchik R, Dixit VD, Jovanovic M, Stewart SA, Daly MJ, Dmitriev S, Oltz EM, Artyomov MN. Shchukina I, et al. Among authors: shpynov o. Nat Aging. 2021 Jan;1(1):124-141. doi: 10.1038/s43587-020-00002-6. Epub 2020 Nov 23. Nat Aging. 2021. PMID: 34796338 Free PMC article.
Semi-supervised peak calling with SPAN and JBR genome browser.
Shpynov O, Dievskii A, Chernyatchik R, Tsurinov P, Artyomov MN. Shpynov O, et al. Bioinformatics. 2021 Nov 18;37(22):4235-4237. doi: 10.1093/bioinformatics/btab376. Bioinformatics. 2021. PMID: 34019098 Free PMC article.
Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection.
Huynh JP, Lin CC, Kimmey JM, Jarjour NN, Schwarzkopf EA, Bradstreet TR, Shchukina I, Shpynov O, Weaver CT, Taneja R, Artyomov MN, Edelson BT, Stallings CL. Huynh JP, et al. Among authors: shpynov o. J Exp Med. 2018 Jul 2;215(7):1823-1838. doi: 10.1084/jem.20171704. Epub 2018 May 17. J Exp Med. 2018. PMID: 29773644 Free PMC article.