N-myristoylation and Ca2+ binding of calcineurin B homologous protein CHP3 are required to enhance Na+/H+ exchanger NHE1 half-life and activity at the plasma membrane.
Zaun HC, Shrier A, Orlowski J.
Zaun HC, et al. Among authors: shrier a.
J Biol Chem. 2012 Oct 26;287(44):36883-95. doi: 10.1074/jbc.M112.394700. Epub 2012 Sep 14.
J Biol Chem. 2012.
PMID: 22984264
Free PMC article.
Previous work has shown that the heart-enriched isoform, CHP3, regulates the plasmalemmal Na(+)/H(+) exchanger NHE1 isoform by enhancing its rate of oligosaccharide maturation and exocytosis as well as its half-life and transport activity at the cell surface (Zaun, H. C., Shri …
Previous work has shown that the heart-enriched isoform, CHP3, regulates the plasmalemmal Na(+)/H(+) exchanger NHE1 isoform by enhancing its …