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Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis.
Abe K, Ikeda M, Ide T, Tadokoro T, Miyamoto HD, Furusawa S, Tsutsui Y, Miyake R, Ishimaru K, Watanabe M, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H. Abe K, et al. Among authors: furusawa s. Sci Signal. 2022 Nov;15(758):eabn8017. doi: 10.1126/scisignal.abn8017. Epub 2022 Nov 1. Sci Signal. 2022. PMID: 36318618
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury.
Miyamoto HD, Ikeda M, Ide T, Tadokoro T, Furusawa S, Abe K, Ishimaru K, Enzan N, Sada M, Yamamoto T, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H. Miyamoto HD, et al. Among authors: furusawa s. JACC Basic Transl Sci. 2022 Jul 27;7(8):800-819. doi: 10.1016/j.jacbts.2022.03.012. eCollection 2022 Aug. JACC Basic Transl Sci. 2022. PMID: 36061338 Free PMC article.
Cardiac Autoantibodies Against Cardiac Troponin I in Post-Myocardial Infarction Heart Failure: Evaluation in a Novel Murine Model and Applications in Therapeutics.
Furusawa S, Ikeda M, Ide T, Kanamura T, Miyamoto HD, Abe K, Ishimaru K, Watanabe M, Tsutsui Y, Miyake R, Fujita S, Tohyama T, Matsushima S, Baba Y, Tsutsui H. Furusawa S, et al. Circ Heart Fail. 2023 Oct;16(10):e010347. doi: 10.1161/CIRCHEARTFAILURE.122.010347. Epub 2023 Jul 31. Circ Heart Fail. 2023. PMID: 37522180
Deferasirox Targeting Ferroptosis Synergistically Ameliorates Myocardial Ischemia Reperfusion Injury in Conjunction With Cyclosporine A.
Ishimaru K, Ikeda M, Miyamoto HD, Furusawa S, Abe K, Watanabe M, Kanamura T, Fujita S, Nishimura R, Toyohara T, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H, Ide T. Ishimaru K, et al. Among authors: furusawa s. J Am Heart Assoc. 2024 Jan 2;13(1):e031219. doi: 10.1161/JAHA.123.031219. Epub 2023 Dec 29. J Am Heart Assoc. 2024. PMID: 38158218 Free PMC article.
Excessive Hypoxia-Inducible Factor-1α Expression Induces Cardiac Rupture via p53-Dependent Apoptosis After Myocardial Infarction.
Ikeda M, Ide T, Tadokoro T, Miyamoto HD, Ikeda S, Okabe K, Ishikita A, Sato M, Abe K, Furusawa S, Ishimaru K, Matsushima S, Tsutsui H. Ikeda M, et al. Among authors: furusawa s. J Am Heart Assoc. 2021 Sep 7;10(17):e020895. doi: 10.1161/JAHA.121.020895. Epub 2021 Sep 2. J Am Heart Assoc. 2021. PMID: 34472375 Free PMC article.
Physical mechanism of core-collapse supernovae that neutrinos drive.
Yamada S, Nagakura H, Akaho R, Harada A, Furusawa S, Iwakami W, Okawa H, Matsufuru H, Sumiyoshi K. Yamada S, et al. Among authors: furusawa s. Proc Jpn Acad Ser B Phys Biol Sci. 2024;100(3):190-233. doi: 10.2183/pjab.100.015. Proc Jpn Acad Ser B Phys Biol Sci. 2024. PMID: 38462501 Free article. Review.