Silverman RB - Search Results

1

Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF₃).

Butrin A, Beaupre BA, Kadamandla N, Zhao P, Shen S, Silverman RB, Moran GR, Liu D. Butrin A, et al. Among authors: silverman rb. ACS Chem Biol. 2021 Jan 15;16(1):67-75. doi: 10.1021/acschembio.0c00728. Epub 2020 Dec 14. ACS Chem Biol. 2021. PMID: 33316155 Free PMC article.

2

Time-dependent inhibition of gamma-aminobutyric acid aminotransferase, by 3-hydroxybenzylhydrazine.

Lightcap ES, Hopkins MH, Olson GT, Silverman RB. Lightcap ES, et al. Among authors: silverman rb. Bioorg Med Chem. 1995 May;3(5):579-85. doi: 10.1016/0968-0896(95)00070-w. Bioorg Med Chem. 1995. PMID: 7648206

3

Mechanism-based inactivation of gamma-aminobutyric acid aminotransferase by 3-amino-4-fluorobutanoic acid.

Silverman RB, Roscher CL. Silverman RB, et al. Bioorg Med Chem. 1996 Sep;4(9):1521-35. doi: 10.1016/0968-0896(96)00145-9. Bioorg Med Chem. 1996. PMID: 8894109

4

Syntheses of (Z)-and (E)-4-amino-2-(trifluoromethyl)-2-butenoic acid and their inactivation of gamma-aminobutyric acid aminotransferase.

Johnson TR, Silverman RB. Johnson TR, et al. Among authors: silverman rb. Bioorg Med Chem. 1999 Aug;7(8):1625-36. doi: 10.1016/s0968-0896(99)00091-7. Bioorg Med Chem. 1999. PMID: 10482455

5

Design of a conformationally restricted analogue of the antiepilepsy drug Vigabatrin that directs its mechanism of inactivation of gamma-aminobutyric acid aminotransferase.

Choi S, Storici P, Schirmer T, Silverman RB. Choi S, et al. Among authors: silverman rb. J Am Chem Soc. 2002 Feb 27;124(8):1620-4. doi: 10.1021/ja011968d. J Am Chem Soc. 2002. PMID: 11853435

6

Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification.

Zhu Y, Nikolic D, Van Breemen RB, Silverman RB. Zhu Y, et al. Among authors: silverman rb. J Am Chem Soc. 2005 Jan 26;127(3):858-68. doi: 10.1021/ja0445645. J Am Chem Soc. 2005. PMID: 15656623

7

(+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway.

Wang Z, Yuan H, Nikolic D, Van Breemen RB, Silverman RB. Wang Z, et al. Among authors: silverman rb. Biochemistry. 2006 Dec 5;45(48):14513-22. doi: 10.1021/bi061592m. Biochemistry. 2006. PMID: 17128990 Free PMC article.

8

Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase.

Yuan H, Silverman RB. Yuan H, et al. Among authors: silverman rb. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1651-4. doi: 10.1016/j.bmcl.2006.12.119. Epub 2007 Jan 17. Bioorg Med Chem Lett. 2007. PMID: 17267220 Free PMC article.

9

Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".

Liu D, Pozharski E, Lepore BW, Fu M, Silverman RB, Petsko GA, Ringe D. Liu D, et al. Among authors: silverman rb. Biochemistry. 2007 Sep 18;46(37):10517-27. doi: 10.1021/bi700663n. Epub 2007 Aug 22. Biochemistry. 2007. PMID: 17713924

10

Chiral discrimination among aminotransferases: inactivation by 4-amino-4,5-dihydrothiophenecarboxylic acid.

Lepore BW, Liu D, Peng Y, Fu M, Yasuda C, Manning JM, Silverman RB, Ringe D. Lepore BW, et al. Among authors: silverman rb. Biochemistry. 2010 Apr 13;49(14):3138-47. doi: 10.1021/bi902052x. Biochemistry. 2010. PMID: 20192272

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