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Combined SRPK and AKT pharmacological inhibition is synergistic in T-cell acute lymphoblastic leukemia cells.
Siqueira RP, Caetano MMM, de Souza LÂ, Dos Passos PMS, Simaroli NB, Barros MVA, de Souza APM, de Oliveira LL, Silva-Júnior A, Fietto JLR, Teixeira RR, Teixeira FR, Bressan GC. Siqueira RP, et al. Among authors: simaroli nb. Toxicol In Vitro. 2020 Jun;65:104777. doi: 10.1016/j.tiv.2020.104777. Epub 2020 Jan 18. Toxicol In Vitro. 2020. PMID: 31962201 Free article.
The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway.
Spagnol V, Oliveira CAB, Randle SJ, Passos PMS, Correia CRSTB, Simaroli NB, Oliveira JS, Mevissen TET, Medeiros AC, Gomes MD, Komander D, Laman H, Teixeira FR. Spagnol V, et al. Among authors: simaroli nb. Biochim Biophys Acta Gen Subj. 2021 Jan;1865(1):129754. doi: 10.1016/j.bbagen.2020.129754. Epub 2020 Sep 30. Biochim Biophys Acta Gen Subj. 2021. PMID: 33010352 Free PMC article.