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Page 1
Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1.
Janssen M, Schmidt C, Bruch PM, Blank MF, Rohde C, Waclawiczek A, Heid D, Renders S, Göllner S, Vierbaum L, Besenbeck B, Herbst SA, Knoll M, Kolb C, Przybylla A, Weidenauer K, Ludwig AK, Fabre M, Gu M, Schlenk RF, Stölzel F, Bornhäuser M, Röllig C, Platzbecker U, Baldus C, Serve H, Sauer T, Raffel S, Pabst C, Vassiliou G, Vick B, Jeremias I, Trumpp A, Krijgsveld J, Müller-Tidow C, Dietrich S. Janssen M, et al. Among authors: renders s. Blood. 2022 Dec 15;140(24):2594-2610. doi: 10.1182/blood.2021014241. Blood. 2022. PMID: 35857899 Free article.
Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax.
Waclawiczek A, Leppä AM, Renders S, Stumpf K, Reyneri C, Betz B, Janssen M, Shahswar R, Donato E, Karpova D, Thiel V, Unglaub JM, Grabowski S, Gryzik S, Vierbaum L, Schlenk RF, Röllig C, Hundemer M, Pabst C, Heuser M, Raffel S, Müller-Tidow C, Sauer T, Trumpp A. Waclawiczek A, et al. Among authors: renders s. Cancer Discov. 2023 Jun 2;13(6):1408-1427. doi: 10.1158/2159-8290.CD-22-0939. Cancer Discov. 2023. PMID: 36892565 Free PMC article.
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.
Hernández-Malmierca P, Vonficht D, Schnell A, Uckelmann HJ, Bollhagen A, Mahmoud MAA, Landua SL, van der Salm E, Trautmann CL, Raffel S, Grünschläger F, Lutz R, Ghosh M, Renders S, Correia N, Donato E, Dixon KO, Hirche C, Andresen C, Robens C, Werner PS, Boch T, Eisel D, Osen W, Pilz F, Przybylla A, Klein C, Buchholz F, Milsom MD, Essers MAG, Eichmüller SB, Hofmann WK, Nowak D, Hübschmann D, Hundemer M, Thiede C, Bullinger L, Müller-Tidow C, Armstrong SA, Trumpp A, Kuchroo VK, Haas S. Hernández-Malmierca P, et al. Among authors: renders s. Cell Stem Cell. 2022 May 5;29(5):760-775.e10. doi: 10.1016/j.stem.2022.04.007. Cell Stem Cell. 2022. PMID: 35523139 Free PMC article.
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A. Cabezas-Wallscheid N, et al. Among authors: renders s. Cell. 2017 May 18;169(5):807-823.e19. doi: 10.1016/j.cell.2017.04.018. Epub 2017 May 4. Cell. 2017. PMID: 28479188 Free article.
Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells.
Sommerkamp P, Romero-Mulero MC, Narr A, Ladel L, Hustin L, Schönberger K, Renders S, Altamura S, Zeisberger P, Jäcklein K, Klimmeck D, Rodriguez-Fraticelli A, Camargo FD, Perié L, Trumpp A, Cabezas-Wallscheid N. Sommerkamp P, et al. Among authors: renders s. Blood. 2021 Jun 10;137(23):3218-3224. doi: 10.1182/blood.2020007876. Blood. 2021. PMID: 33754628 Free PMC article.
GPRC5C drives branched-chain amino acid metabolism in leukemogenesis.
Zhang YW, Velasco-Hernandez T, Mess J, Lalioti ME, Romero-Mulero MC, Obier N, Karantzelis N, Rettkowski J, Schönberger K, Karabacz N, Jäcklein K, Morishima T, Trincado JL, Romecin P, Martinez A, Takizawa H, Shoumariyeh K, Renders S, Zeiser R, Pahl HL, Béliveau F, Hébert J, Lehnertz B, Sauvageau G, Menendez P, Cabezas-Wallscheid N. Zhang YW, et al. Among authors: renders s. Blood Adv. 2023 Dec 26;7(24):7525-7538. doi: 10.1182/bloodadvances.2023010460. Blood Adv. 2023. PMID: 37639313 Free PMC article.
The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia.
Weidenauer K, Schmidt C, Rohde C, Pauli C, Blank MF, Heid D, Waclawiczek A, Corbacioglu A, Göllner S, Lotze M, Vierbaum L, Renders S, Krijgsveld J, Raffel S, Sauer T, Trumpp A, Pabst C, Müller-Tidow C, Janssen M. Weidenauer K, et al. Among authors: renders s. Leukemia. 2023 Aug;37(8):1611-1625. doi: 10.1038/s41375-023-01951-8. Epub 2023 Jul 6. Leukemia. 2023. PMID: 37414921 Free PMC article.
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1.
Renders S, Svendsen AF, Panten J, Rama N, Maryanovich M, Sommerkamp P, Ladel L, Redavid AR, Gibert B, Lazare S, Ducarouge B, Schönberger K, Narr A, Tourbez M, Dethmers-Ausema B, Zwart E, Hotz-Wagenblatt A, Zhang D, Korn C, Zeisberger P, Przybylla A, Sohn M, Mendez-Ferrer S, Heikenwälder M, Brune M, Klimmeck D, Bystrykh L, Frenette PS, Mehlen P, de Haan G, Cabezas-Wallscheid N, Trumpp A. Renders S, et al. Nat Commun. 2021 Jan 27;12(1):608. doi: 10.1038/s41467-020-20801-0. Nat Commun. 2021. PMID: 33504783 Free PMC article.
Protein tyrosine kinase 2b inhibition reverts niche-associated resistance to tyrosine kinase inhibitors in AML.
Allert C, Waclawiczek A, Zimmermann SMN, Göllner S, Heid D, Janssen M, Renders S, Rohde C, Bauer M, Bruckmann M, Zinz R, Pauli C, Besenbeck B, Wickenhauser C, Trumpp A, Krijgsveld J, Müller-Tidow C, Blank MF. Allert C, et al. Among authors: renders s. Leukemia. 2022 Oct;36(10):2418-2429. doi: 10.1038/s41375-022-01687-x. Epub 2022 Sep 2. Leukemia. 2022. PMID: 36056084 Free PMC article.
Future directions in preclinical and translational cancer neuroscience research.
Demir IE, Mota Reyes C, Alrawashdeh W, Ceyhan GO, Deborde S, Friess H, Görgülü K, Istvanffy R, Jungwirth D, Kuner R, Maryanovich M, Na'ara S, Renders S, Saloman JL, Scheff NN, Steenfadt H, Stupakov P, Thiel V, Verma D, Yilmaz BS, White RA, Wang TC, Wong RJ, Frenette PS, Gil Z; Neural Influences in Cancer (NIC) International Research Consortium; Davis BM. Demir IE, et al. Among authors: renders s. Nat Cancer. 2021 Nov;1:1027-1031. doi: 10.1038/s43018-020-00146-9. Epub 2020 Nov 17. Nat Cancer. 2021. PMID: 34327335 Free PMC article.
21 results