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Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent.
Velaparthi U, Darne CP, Warrier J, Liu P, Rahaman H, Augustine-Rauch K, Parrish K, Yang Z, Swanson J, Brown J, Dhar G, Anandam A, Holenarsipur VK, Palanisamy K, Wautlet BS, Fereshteh MP, Lippy J, Tebben AJ, Sheriff S, Ruzanov M, Yan C, Gupta A, Gupta AK, Vetrichelvan M, Mathur A, Gelman M, Singh R, Kinsella T, Murtaza A, Fargnoli J, Vite G, Borzilleri RM. Velaparthi U, et al. Among authors: singh r. ACS Med Chem Lett. 2020 Jan 28;11(2):172-178. doi: 10.1021/acsmedchemlett.9b00552. eCollection 2020 Feb 13. ACS Med Chem Lett. 2020. PMID: 32071685 Free PMC article.
Discovery and characterization of substituted diphenyl heterocyclic compounds as potent and selective inhibitors of hepatitis C virus replication.
Huang P, Goff DA, Huang Q, Martinez A, Xu X, Crowder S, Issakani SD, Anderson E, Sheng N, Achacoso P, Yen A, Kinsella T, Darwish IS, Kolluri R, Hong H, Qu K, Stauffer E, Goldstein E, Singh R, Payan DG, Lu HH. Huang P, et al. Among authors: singh r. Antimicrob Agents Chemother. 2008 Apr;52(4):1419-29. doi: 10.1128/AAC.00525-07. Epub 2008 Jan 28. Antimicrob Agents Chemother. 2008. PMID: 18227176 Free PMC article.
Bicyclic pyrimidine compounds as potent IRAK4 inhibitors.
Chen Y, Tso K, Heckrodt TJ, Li H, Yen R, Lin N, Singh R, Taylor V, Masuda ES, Park G, Payan DG. Chen Y, et al. Among authors: singh r. Bioorg Med Chem Lett. 2022 Oct 1;73:128900. doi: 10.1016/j.bmcl.2022.128900. Epub 2022 Jul 18. Bioorg Med Chem Lett. 2022. PMID: 35863718
Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen.
McLaughlin J, Markovtsov V, Li H, Wong S, Gelman M, Zhu Y, Franci C, Lang D, Pali E, Lasaga J, Low C, Zhao F, Chang B, Gururaja TL, Xu W, Baluom M, Sweeny D, Carroll D, Sran A, Thota S, Parmer M, Romane A, Clemens G, Grossbard E, Qu K, Jenkins Y, Kinoshita T, Taylor V, Holland SJ, Argade A, Singh R, Pine P, Payan DG, Hitoshi Y. McLaughlin J, et al. Among authors: singh r. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113. doi: 10.1007/s00432-009-0641-1. J Cancer Res Clin Oncol. 2010. PMID: 19609559
Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice.
Baltgalvis KA, White K, Li W, Claypool MD, Lang W, Alcantara R, Singh BK, Friera AM, McLaughlin J, Hansen D, McCaughey K, Nguyen H, Smith IJ, Godinez G, Shaw SJ, Goff D, Singh R, Markovtsov V, Sun TQ, Jenkins Y, Uy G, Li Y, Pan A, Gururaja T, Lau D, Park G, Hitoshi Y, Payan DG, Kinsella TM. Baltgalvis KA, et al. Among authors: singh bk, singh r. Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1128-45. doi: 10.1152/ajpheart.00839.2013. Epub 2014 Feb 21. Am J Physiol Heart Circ Physiol. 2014. PMID: 24561866 Free PMC article.
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