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A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation.
Tadele DS, Robertson J, Crispin R, Herrera MC, Chlubnová M, Piechaczyk L, Ayuda-Durán P, Singh SK, Gedde-Dahl T, Fløisand Y, Skavland J, Wesche J, Gjertsen BT, Enserink JM. Tadele DS, et al. Among authors: singh sk. J Biol Chem. 2021 Jan-Jun;296:100179. doi: 10.1074/jbc.RA120.015285. Epub 2020 Dec 17. J Biol Chem. 2021. PMID: 33303632 Free PMC article.
GAK and PRKCD are positive regulators of PRKN-independent mitophagy.
Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Schultz SW, Aman Y, Lystad AH, Singh S, Singh S, Wesche J, Fang EF, Simonsen A. Munson MJ, et al. Nat Commun. 2021 Oct 20;12(1):6101. doi: 10.1038/s41467-021-26331-7. Nat Commun. 2021. PMID: 34671015 Free PMC article.
Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma.
Fiorito E, Szybowska P, Haugsten EM, Kostas M, Øy GF, Wiedlocha A, Singh S, Nakken S, Mælandsmo GM, Fletcher JA, Meza-Zepeda LA, Wesche J. Fiorito E, et al. Br J Cancer. 2022 Nov;127(11):1939-1953. doi: 10.1038/s41416-022-01973-6. Epub 2022 Sep 12. Br J Cancer. 2022. PMID: 36097178 Free PMC article.
4,491 results