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Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics.
Wambaugh JF, Hughes MF, Ring CL, MacMillan DK, Ford J, Fennell TR, Black SR, Snyder RW, Sipes NS, Wetmore BA, Westerhout J, Setzer RW, Pearce RG, Simmons JE, Thomas RS. Wambaugh JF, et al. Among authors: sipes ns. Toxicol Sci. 2018 May 1;163(1):152-169. doi: 10.1093/toxsci/kfy020. Toxicol Sci. 2018. PMID: 29385628 Free PMC article.
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.
Knudsen TB, Houck KA, Sipes NS, Singh AV, Judson RS, Martin MT, Weissman A, Kleinstreuer NC, Mortensen HM, Reif DM, Rabinowitz JR, Setzer RW, Richard AM, Dix DJ, Kavlock RJ. Knudsen TB, et al. Among authors: sipes ns. Toxicology. 2011 Mar 28;282(1-2):1-15. doi: 10.1016/j.tox.2010.12.010. Epub 2011 Jan 18. Toxicology. 2011. PMID: 21251949
Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.
Judson RS, Magpantay FM, Chickarmane V, Haskell C, Tania N, Taylor J, Xia M, Huang R, Rotroff DM, Filer DL, Houck KA, Martin MT, Sipes N, Richard AM, Mansouri K, Setzer RW, Knudsen TB, Crofton KM, Thomas RS. Judson RS, et al. Toxicol Sci. 2015 Nov;148(1):137-54. doi: 10.1093/toxsci/kfv168. Epub 2015 Aug 13. Toxicol Sci. 2015. PMID: 26272952 Free PMC article.
Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes.
Leung MC, Phuong J, Baker NC, Sipes NS, Klinefelter GR, Martin MT, McLaurin KW, Setzer RW, Darney SP, Judson RS, Knudsen TB. Leung MC, et al. Among authors: sipes ns. Environ Health Perspect. 2016 Jul;124(7):1050-61. doi: 10.1289/ehp.1510385. Epub 2015 Dec 11. Environ Health Perspect. 2016. PMID: 26662846 Free PMC article.
We confirmed the known role of estrogen and androgen signaling pathways in rodent TDS, and importantly, broadened the list of molecular targets to include retinoic acid signaling, vascular remodeling proteins, G-protein coupled receptors (GPCRs), and cytochrome P450s. CITATION: L …
We confirmed the known role of estrogen and androgen signaling pathways in rodent TDS, and importantly, broadened the list of molecular targ …
51 results