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The antioxidant transcription factor Nrf2 modulates the stress response and phenotype of malignant as well as premalignant pancreatic ductal epithelial cells by inducing expression of the ATF3 splicing variant ΔZip2.
Kha ML, Hesse L, Deisinger F, Sipos B, Röcken C, Arlt A, Sebens S, Helm O, Schäfer H. Kha ML, et al. Among authors: sipos b. Oncogene. 2019 Feb;38(9):1461-1476. doi: 10.1038/s41388-018-0518-3. Epub 2018 Oct 9. Oncogene. 2019. PMID: 30302023
The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1.
Genrich G, Kruppa M, Lenk L, Helm O, Broich A, Freitag-Wolf S, Röcken C, Sipos B, Schäfer H, Sebens S. Genrich G, et al. Among authors: sipos b. BMC Cancer. 2016 Feb 25;16:155. doi: 10.1186/s12885-016-2191-7. BMC Cancer. 2016. PMID: 26915435 Free PMC article.
Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer.
Geismann C, Morscheck M, Koch D, Bergmann F, Ungefroren H, Arlt A, Tsao MS, Bachem MG, Altevogt P, Sipos B, Fölsch UR, Schäfer H, Müerköster SS. Geismann C, et al. Among authors: sipos b. Cancer Res. 2009 May 15;69(10):4517-26. doi: 10.1158/0008-5472.CAN-08-3493. Epub 2009 May 12. Cancer Res. 2009. PMID: 19435915
Comparative characterization of stroma cells and ductal epithelium in chronic pancreatitis and pancreatic ductal adenocarcinoma.
Helm O, Mennrich R, Petrick D, Goebel L, Freitag-Wolf S, Röder C, Kalthoff H, Röcken C, Sipos B, Kabelitz D, Schäfer H, Oberg HH, Wesch D, Sebens S. Helm O, et al. Among authors: sipos b. PLoS One. 2014 May 5;9(5):e94357. doi: 10.1371/journal.pone.0094357. eCollection 2014. PLoS One. 2014. PMID: 24797069 Free PMC article. Clinical Trial.
CD4+ T cells potently induce epithelial-mesenchymal-transition in premalignant and malignant pancreatic ductal epithelial cells-novel implications of CD4+ T cells in pancreatic cancer development.
Goebel L, Grage-Griebenow E, Gorys A, Helm O, Genrich G, Lenk L, Wesch D, Ungefroren H, Freitag-Wolf S, Sipos B, Röcken C, Schäfer H, Sebens S. Goebel L, et al. Among authors: sipos b. Oncoimmunology. 2015 Jan 22;4(4):e1000083. doi: 10.1080/2162402X.2014.1000083. eCollection 2015 Apr. Oncoimmunology. 2015. PMID: 26137395 Free PMC article.
292 results