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Chemical and optical control of CRISPR-associated nucleases.
Modell AE, Siriwardena SU, Shoba VM, Li X, Choudhary A. Modell AE, et al. Among authors: siriwardena su. Curr Opin Chem Biol. 2021 Feb;60:113-121. doi: 10.1016/j.cbpa.2020.10.003. Epub 2020 Nov 27. Curr Opin Chem Biol. 2021. PMID: 33253976 Review.
Phosphorylation-Inducing Chimeric Small Molecules.
Siriwardena SU, Munkanatta Godage DNP, Shoba VM, Lai S, Shi M, Wu P, Chaudhary SK, Schreiber SL, Choudhary A. Siriwardena SU, et al. J Am Chem Soc. 2020 Aug 19;142(33):14052-14057. doi: 10.1021/jacs.0c05537. Epub 2020 Aug 4. J Am Chem Soc. 2020. PMID: 32787262
Synthetic Reprogramming of Kinases Expands Cellular Activities of Proteins.
Shoba VM, Munkanatta Godage DNP, Chaudhary SK, Deb A, Siriwardena SU, Choudhary A. Shoba VM, et al. Among authors: siriwardena su. Angew Chem Int Ed Engl. 2022 Jul 18;61(29):e202202770. doi: 10.1002/anie.202202770. Epub 2022 May 31. Angew Chem Int Ed Engl. 2022. PMID: 35641438 Free PMC article.
Development and Applications of Chimera Platforms for Tyrosine Phosphorylation.
Pergu R, Shoba VM, Chaudhary SK, Munkanatta Godage DNP, Deb A, Singha S, Dhawa U, Singh P, Anokhina V, Singh S, Siriwardena SU, Choudhary A. Pergu R, et al. Among authors: siriwardena su. ACS Cent Sci. 2023 Aug 9;9(8):1558-1566. doi: 10.1021/acscentsci.3c00200. eCollection 2023 Aug 23. ACS Cent Sci. 2023. PMID: 37637727 Free PMC article.
A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.
Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dančík V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, Clemons PA, Wagner BK, Choudhary A. Maji B, et al. Among authors: siriwardena su. Cell. 2019 May 2;177(4):1067-1079.e19. doi: 10.1016/j.cell.2019.04.009. Cell. 2019. PMID: 31051099 Free PMC article.
APOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response.
Conner KL, Shaik AN, Marshall KA, Floyd AM, Ekinci E, Lindquist J, Sawant A, Lei W, Adolph MB, Chelico L, Siriwardena SU, Bhagwat A, Kim S, Cote ML, Patrick SM. Conner KL, et al. Among authors: siriwardena su. NAR Cancer. 2020 Dec;2(4):zcaa033. doi: 10.1093/narcan/zcaa033. Epub 2020 Nov 6. NAR Cancer. 2020. PMID: 33196045 Free PMC article.