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Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.
Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ. Liu F, et al. Among authors: sisson th. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25502501 Free PMC article. Clinical Trial.
The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice.
Courey AJ, Horowitz JC, Kim KK, Koh TJ, Novak ML, Subbotina N, Warnock M, Xue B, Cunningham AK, Lin Y, Goldklang MP, Simon RH, Lawrence DA, Sisson TH. Courey AJ, et al. Among authors: sisson th. Blood. 2011 Aug 25;118(8):2313-21. doi: 10.1182/blood-2010-12-324574. Epub 2011 Jul 6. Blood. 2011. PMID: 21734232 Free PMC article.
Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis.
Horowitz JC, Ajayi IO, Kulasekaran P, Rogers DS, White JB, Townsend SK, White ES, Nho RS, Higgins PD, Huang SK, Sisson TH. Horowitz JC, et al. Among authors: sisson th. Int J Biochem Cell Biol. 2012 Jan;44(1):158-69. doi: 10.1016/j.biocel.2011.10.011. Epub 2011 Oct 25. Int J Biochem Cell Biol. 2012. PMID: 22041029 Free PMC article.
PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury.
Osterholzer JJ, Christensen PJ, Lama V, Horowitz JC, Hattori N, Subbotina N, Cunningham A, Lin Y, Murdock BJ, Morey RE, Olszewski MA, Lawrence DA, Simon RH, Sisson TH. Osterholzer JJ, et al. Among authors: sisson th. J Pathol. 2012 Oct;228(2):170-80. doi: 10.1002/path.3992. Epub 2012 Jun 6. J Pathol. 2012. PMID: 22262246 Free PMC article.
Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis.
Naik PK, Bozyk PD, Bentley JK, Popova AP, Birch CM, Wilke CA, Fry CD, White ES, Sisson TH, Tayob N, Carnemolla B, Orecchia P, Flaherty KR, Hershenson MB, Murray S, Martinez FJ, Moore BB; COMET Investigators. Naik PK, et al. Among authors: sisson th. Am J Physiol Lung Cell Mol Physiol. 2012 Dec 15;303(12):L1046-56. doi: 10.1152/ajplung.00139.2012. Epub 2012 Oct 5. Am J Physiol Lung Cell Mol Physiol. 2012. PMID: 23043074 Free PMC article.
57 results