Skele KL - Search Results

1

Frequent activation of AKT2 kinase in human pancreatic carcinomas.

Altomare DA, Tanno S, De Rienzo A, Klein-Szanto AJ, Tanno S, Skele KL, Hoffman JP, Testa JR. Altomare DA, et al. Among authors: skele kl. J Cell Biochem. 2002;87(4):470-6. doi: 10.1002/jcb.10287. J Cell Biochem. 2002. PMID: 14735903

2

AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth.

Altomare DA, Wang HQ, Skele KL, De Rienzo A, Klein-Szanto AJ, Godwin AK, Testa JR. Altomare DA, et al. Among authors: skele kl. Oncogene. 2004 Jul 29;23(34):5853-7. doi: 10.1038/sj.onc.1207721. Oncogene. 2004. PMID: 15208673

3

Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.

Wang HQ, Altomare DA, Skele KL, Poulikakos PI, Kuhajda FP, Di Cristofano A, Testa JR. Wang HQ, et al. Among authors: skele kl. Oncogene. 2005 May 19;24(22):3574-82. doi: 10.1038/sj.onc.1208463. Oncogene. 2005. PMID: 15806173

4

Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth.

Altomare DA, You H, Xiao GH, Ramos-Nino ME, Skele KL, De Rienzo A, Jhanwar SC, Mossman BT, Kane AB, Testa JR. Altomare DA, et al. Among authors: skele kl. Oncogene. 2005 Sep 8;24(40):6080-9. doi: 10.1038/sj.onc.1208744. Oncogene. 2005. PMID: 15897870

5

The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression.

Xiao GH, Gallagher R, Shetler J, Skele K, Altomare DA, Pestell RG, Jhanwar S, Testa JR. Xiao GH, et al. Mol Cell Biol. 2005 Mar;25(6):2384-94. doi: 10.1128/MCB.25.6.2384-2394.2005. Mol Cell Biol. 2005. PMID: 15743831 Free PMC article.

6

A mouse model recapitulating molecular features of human mesothelioma.

Altomare DA, Vaslet CA, Skele KL, De Rienzo A, Devarajan K, Jhanwar SC, McClatchey AI, Kane AB, Testa JR. Altomare DA, et al. Among authors: skele kl. Cancer Res. 2005 Sep 15;65(18):8090-5. doi: 10.1158/0008-5472.CAN-05-2312. Cancer Res. 2005. PMID: 16166281

7

Seneca Valley virus, a systemically deliverable oncolytic picornavirus, and the treatment of neuroendocrine cancers.

Reddy PS, Burroughs KD, Hales LM, Ganesh S, Jones BH, Idamakanti N, Hay C, Li SS, Skele KL, Vasko AJ, Yang J, Watkins DN, Rudin CM, Hallenbeck PL. Reddy PS, et al. Among authors: skele kl. J Natl Cancer Inst. 2007 Nov 7;99(21):1623-33. doi: 10.1093/jnci/djm198. Epub 2007 Oct 30. J Natl Cancer Inst. 2007. PMID: 17971529 Free PMC article.

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