Smith GC - Search Results

1

Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors.

Rewcastle GW, Kolekar S, Buchanan CM, Gamage SA, Giddens AC, Tsang KY, Kendall JD, Singh R, Lee WJ, Smith GC, Han W, Matthews DJ, Denny WA, Shepherd PR, Jamieson SMF. Rewcastle GW, et al. Among authors: smith gc. Oncotarget. 2017 Jul 18;8(29):47725-47740. doi: 10.18632/oncotarget.17730. Oncotarget. 2017. PMID: 28537878 Free PMC article.

2

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo.

Smith GC, Ong WK, Rewcastle GW, Kendall JD, Han W, Shepherd PR. Smith GC, et al. Biochem J. 2012 Feb 15;442(1):161-9. doi: 10.1042/BJ20111913. Biochem J. 2012. PMID: 22142257 Free PMC article.

3

Extended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength.

Smith GC, Ong WK, Costa JL, Watson M, Cornish J, Grey A, Gamble GD, Dickinson M, Leung S, Rewcastle GW, Han W, Shepherd PR. Smith GC, et al. FEBS J. 2013 Nov;280(21):5337-49. doi: 10.1111/febs.12428. Epub 2013 Aug 12. FEBS J. 2013. PMID: 23837532 Free article.

4

Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling.

Chowdhury MK, Wu LE, Coleman JL, Smith NJ, Morris MJ, Shepherd PR, Smith GC. Chowdhury MK, et al. Among authors: smith nj, smith gc. Biochem J. 2016 May 1;473(9):1247-55. doi: 10.1042/BCJ20160121. Epub 2016 Mar 10. Biochem J. 2016. PMID: 26964897

5

Olanzapine effects on body composition, food preference, glucose metabolism and insulin sensitivity in the rat.

Smith GC, Vickers MH, Shepherd PR. Smith GC, et al. Arch Physiol Biochem. 2011 Oct;117(4):241-9. doi: 10.3109/13813455.2011.576681. Epub 2011 Jun 15. Arch Physiol Biochem. 2011. PMID: 21671852

6

Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production and increase glucagon release in obese rats: implications for glucose metabolism and food choice behaviour.

Smith GC, Vickers MH, Cognard E, Shepherd PR. Smith GC, et al. Schizophr Res. 2009 Nov;115(1):30-40. doi: 10.1016/j.schres.2009.07.011. Epub 2009 Aug 12. Schizophr Res. 2009. PMID: 19679451

7

The activation of the Akt/PKB signalling pathway in the brains of clozapine-exposed rats is linked to hyperinsulinemia and not a direct drug effect.

Smith GC, McEwen H, Steinberg JD, Shepherd PR. Smith GC, et al. Psychopharmacology (Berl). 2014 Dec;231(23):4553-60. doi: 10.1007/s00213-014-3608-0. Epub 2014 May 7. Psychopharmacology (Berl). 2014. PMID: 24800899

8

Limited Metabolic Effect of the CREBRF^R457Q Obesity Variant in Mice.

Metcalfe LK, Shepherd PR, Smith GC, Turner N. Metcalfe LK, et al. Among authors: smith gc. Cells. 2022 Jan 31;11(3):497. doi: 10.3390/cells11030497. Cells. 2022. PMID: 35159305 Free PMC article.

9

Atypical antipsychotic drugs induce derangements in glucose homeostasis by acutely increasing glucagon secretion and hepatic glucose output in the rat.

Smith GC, Chaussade C, Vickers M, Jensen J, Shepherd PR. Smith GC, et al. Diabetologia. 2008 Dec;51(12):2309-17. doi: 10.1007/s00125-008-1152-3. Epub 2008 Oct 9. Diabetologia. 2008. PMID: 18843478

10

Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes.

Chowdhury MK, Turner N, Bentley NL, Das A, Wu LE, Richani D, Bustamante S, Gilchrist RB, Morris MJ, Shepherd PR, Smith GC. Chowdhury MK, et al. Among authors: smith gc. Sci Rep. 2017 Jan 5;7:40159. doi: 10.1038/srep40159. Sci Rep. 2017. PMID: 28054648 Free PMC article.

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