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Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.
Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE. Ferdaoussi M, et al. Among authors: smith n. J Clin Invest. 2015 Oct 1;125(10):3847-60. doi: 10.1172/JCI82498. Epub 2015 Sep 21. J Clin Invest. 2015. PMID: 26389676 Free PMC article.
Interleukin-1 signaling contributes to acute islet compensation.
Hajmrle C, Smith N, Spigelman AF, Dai X, Senior L, Bautista A, Ferdaoussi M, MacDonald PE. Hajmrle C, et al. Among authors: smith n. JCI Insight. 2016 Apr 7;1(4):e86055. doi: 10.1172/jci.insight.86055. JCI Insight. 2016. PMID: 27699257 Free PMC article.
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.
Dai XQ, Camunas-Soler J, Briant LJB, Dos Santos T, Spigelman AF, Walker EM, Arrojo E Drigo R, Bautista A, Jones RC, Avrahami D, Lyon J, Nie A, Smith N, Zhang Y, Johnson J, Manning Fox JE, Michelakis ED, Light PE, Kaestner KH, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE. Dai XQ, et al. Among authors: smith n. Cell Metab. 2022 Feb 1;34(2):256-268.e5. doi: 10.1016/j.cmet.2021.12.021. Cell Metab. 2022. PMID: 35108513 Free PMC article.
Impacts of the COVID-19 pandemic on a human research islet program.
Dafoe TJ, Dos Santos T, Spigelman AF, Lyon J, Smith N, Bautista A, MacDonald PE, Manning Fox JE. Dafoe TJ, et al. Among authors: smith n. Islets. 2022 Dec 31;14(1):101-113. doi: 10.1080/19382014.2022.2047571. Islets. 2022. PMID: 35285768 Free PMC article.
5,734 results