Smith RA - Search Results

1

Antiretroviral drug resistance in HIV-2: three amino acid changes are sufficient for classwide nucleoside analogue resistance.

Smith RA, Anderson DJ, Pyrak CL, Preston BD, Gottlieb GS. Smith RA, et al. J Infect Dis. 2009 May 1;199(9):1323-6. doi: 10.1086/597802. J Infect Dis. 2009. PMID: 19358668 Free PMC article.

2

A novel point mutation at position 156 of reverse transcriptase from feline immunodeficiency virus confers resistance to the combination of (-)-beta-2',3'-dideoxy-3'-thiacytidine and 3'-azido-3'-deoxythymidine.

Smith RA, Remington KM, Preston BD, Schinazi RF, North TW. Smith RA, et al. J Virol. 1998 Mar;72(3):2335-40. doi: 10.1128/JVI.72.3.2335-2340.1998. J Virol. 1998. PMID: 9499094 Free PMC article.

3

A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidine.

Smith RA, Klarmann GJ, Stray KM, von Schwedler UK, Schinazi RF, Preston BD, North TW. Smith RA, et al. Antimicrob Agents Chemother. 1999 Aug;43(8):2077-80. doi: 10.1128/AAC.43.8.2077. Antimicrob Agents Chemother. 1999. PMID: 10428942 Free PMC article.

4

Site-specific incorporation of nucleoside analogs by HIV-1 reverse transcriptase and the template grip mutant P157S. Template interactions influence substrate recognition at the polymerase active site.

Klarmann GJ, Smith RA, Schinazi RF, North TW, Preston BD. Klarmann GJ, et al. Among authors: smith ra. J Biol Chem. 2000 Jan 7;275(1):359-66. doi: 10.1074/jbc.275.1.359. J Biol Chem. 2000. PMID: 10617626 Free article.

5

Purifying selection masks the mutational flexibility of HIV-1 reverse transcriptase.

Smith RA, Anderson DJ, Preston BD. Smith RA, et al. J Biol Chem. 2004 Jun 18;279(25):26726-34. doi: 10.1074/jbc.M314038200. Epub 2004 Mar 9. J Biol Chem. 2004. PMID: 15014075 Free article.

6

Lethal mutagenesis of HIV.

Smith RA, Loeb LA, Preston BD. Smith RA, et al. Virus Res. 2005 Feb;107(2):215-28. doi: 10.1016/j.virusres.2004.11.011. Virus Res. 2005. PMID: 15649567 Review.

7

Hypersusceptibility to substrate analogs conferred by mutations in human immunodeficiency virus type 1 reverse transcriptase.

Smith RA, Anderson DJ, Preston BD. Smith RA, et al. J Virol. 2006 Jul;80(14):7169-78. doi: 10.1128/JVI.00322-06. J Virol. 2006. PMID: 16809322 Free PMC article.

8

Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to Zidovudine and other nucleoside analog inhibitors in vitro.

Smith RA, Gottlieb GS, Anderson DJ, Pyrak CL, Preston BD. Smith RA, et al. Antimicrob Agents Chemother. 2008 Jan;52(1):329-32. doi: 10.1128/AAC.01004-07. Epub 2007 Oct 29. Antimicrob Agents Chemother. 2008. PMID: 17967913 Free PMC article.

9

Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: implications for HIV-2 treatment in resouce-limited West Africa.

Gottlieb GS, Badiane NM, Hawes SE, Fortes L, Toure M, Ndour CT, Starling AK, Traore F, Sall F, Wong KG, Cherne SL, Anderson DJ, Dye SA, Smith RA, Mullins JI, Kiviat NB, Sow PS; University of Washington-Dakar HIV-2 Study Group. Gottlieb GS, et al. Among authors: smith ra. Clin Infect Dis. 2009 Feb 15;48(4):476-83. doi: 10.1086/596504. Clin Infect Dis. 2009. PMID: 19143530 Free PMC article.

10

Random-scanning mutagenesis.

Smith RA. Smith RA. Methods Mol Biol. 2010;634:387-97. doi: 10.1007/978-1-60761-652-8_27. Methods Mol Biol. 2010. PMID: 20676998

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