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Substrate variants versus transition state analogues as noncovalent reversible enzyme inhibitors.
Bioorg Med Chem. 2004 Aug 1;12(15):4081-8. doi: 10.1016/j.bmc.2004.05.041.
Bioorg Med Chem. 2004.
PMID: 15246086
A substrate variant as a high-affinity, reversible inhibitor: insight from the X-ray structure of cilastatin bound to membrane dipeptidase.
Smyth TP, Wall JG, Nitanai Y.
Smyth TP, et al.
Bioorg Med Chem. 2003 Mar 20;11(6):991-8. doi: 10.1016/s0968-0896(02)00519-9.
Bioorg Med Chem. 2003.
PMID: 12614884
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Toward the development of a cephalosporin-based dual-release prodrug for use in ADEPT.
Grant JW, Smyth TP.
Grant JW, et al. Among authors: smyth tp.
J Org Chem. 2004 Nov 12;69(23):7965-70. doi: 10.1021/jo048970i.
J Org Chem. 2004.
PMID: 15527277
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Extending the beta-Lactamase-Dependent Prodrug Armory: S-Aminosulfeniminocephalosporins as Dual-Release Prodrugs.
Smyth TP, O'Connor MJ, O'Donnell ME.
Smyth TP, et al.
J Org Chem. 1999 Apr 30;64(9):3132-3138. doi: 10.1021/jo981993a.
J Org Chem. 1999.
PMID: 11674412
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Exploring the chemistry of penicillin as a beta-lactamase-dependent prodrug.
Ruddle CC, Smyth TP.
Ruddle CC, et al. Among authors: smyth tp.
Org Biomol Chem. 2007 Jan 7;5(1):160-8. doi: 10.1039/b614758e. Epub 2006 Nov 22.
Org Biomol Chem. 2007.
PMID: 17164921
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Clean-chemistry synthesis of 2-tetralones in a single-stage acylation-cycloalkylation process.
Gray AD, Smyth TP.
Gray AD, et al. Among authors: smyth tp.
J Org Chem. 2001 Oct 19;66(21):7113-7. doi: 10.1021/jo0158074.
J Org Chem. 2001.
PMID: 11597238
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Penicillins as beta-lactamase-dependent prodrugs: enabling role of a vinyl ester exocyclic to the lactam ring.
Ruddle CC, Smyth TP.
Ruddle CC, et al. Among authors: smyth tp.
Chem Commun (Camb). 2004 Oct 21;(20):2332-3. doi: 10.1039/b409517k. Epub 2004 Sep 7.
Chem Commun (Camb). 2004.
PMID: 15490006
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In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.
Desgranges S, Le Prieult F, Daly A, Lydon J, Brennan M, Rai DK, Subasinghage AP, Hewage CM, Cryan SA, Greene C, McElvaney NG, Smyth TP, Fitzgerald-Hughes D, Humphreys H, Devocelle M.
Desgranges S, et al. Among authors: smyth tp.
Antimicrob Agents Chemother. 2011 May;55(5):2487-9. doi: 10.1128/AAC.01384-10. Epub 2011 Feb 22.
Antimicrob Agents Chemother. 2011.
PMID: 21343449
Free PMC article.
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