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The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling.
Sommer ME, Selent J, Carlsson J, De Graaf C, Gloriam DE, Keseru GM, Kosloff M, Mordalski S, Rizk A, Rosenkilde MM, Sotelo E, Tiemann JKS, Tobin A, Vardjan N, Waldhoer M, Kolb P. Sommer ME, et al. ACS Pharmacol Transl Sci. 2020 Mar 31;3(2):361-370. doi: 10.1021/acsptsci.0c00024. eCollection 2020 Apr 10. ACS Pharmacol Transl Sci. 2020. PMID: 32296774 Free PMC article.
Community guidelines for GPCR ligand bias: IUPHAR review 32.
Kolb P, Kenakin T, Alexander SPH, Bermudez M, Bohn LM, Breinholt CS, Bouvier M, Hill SJ, Kostenis E, Martemyanov KA, Neubig RR, Onaran HO, Rajagopal S, Roth BL, Selent J, Shukla AK, Sommer ME, Gloriam DE. Kolb P, et al. Among authors: sommer me. Br J Pharmacol. 2022 Jul;179(14):3651-3674. doi: 10.1111/bph.15811. Epub 2022 Mar 27. Br J Pharmacol. 2022. PMID: 35106752 Free PMC article. Review.
C-edge loops of arrestin function as a membrane anchor.
Lally CC, Bauer B, Selent J, Sommer ME. Lally CC, et al. Among authors: sommer me. Nat Commun. 2017 Feb 21;8:14258. doi: 10.1038/ncomms14258. Nat Commun. 2017. PMID: 28220785 Free PMC article.
Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation.
Mayer D, Damberger FF, Samarasimhareddy M, Feldmueller M, Vuckovic Z, Flock T, Bauer B, Mutt E, Zosel F, Allain FHT, Standfuss J, Schertler GFX, Deupi X, Sommer ME, Hurevich M, Friedler A, Veprintsev DB. Mayer D, et al. Among authors: sommer me. Nat Commun. 2019 Mar 19;10(1):1261. doi: 10.1038/s41467-019-09204-y. Nat Commun. 2019. PMID: 30890705 Free PMC article.
Molecular mechanism of GPCR-mediated arrestin activation.
Latorraca NR, Wang JK, Bauer B, Townshend RJL, Hollingsworth SA, Olivieri JE, Xu HE, Sommer ME, Dror RO. Latorraca NR, et al. Among authors: sommer me. Nature. 2018 May;557(7705):452-456. doi: 10.1038/s41586-018-0077-3. Epub 2018 May 2. Nature. 2018. PMID: 29720655 Free PMC article.
Crystal structure of pre-activated arrestin p44.
Kim YJ, Hofmann KP, Ernst OP, Scheerer P, Choe HW, Sommer ME. Kim YJ, et al. Among authors: sommer me. Nature. 2013 May 2;497(7447):142-6. doi: 10.1038/nature12133. Epub 2013 Apr 21. Nature. 2013. PMID: 23604253
Crystal structure of a common GPCR-binding interface for G protein and arrestin.
Szczepek M, Beyrière F, Hofmann KP, Elgeti M, Kazmin R, Rose A, Bartl FJ, von Stetten D, Heck M, Sommer ME, Hildebrand PW, Scheerer P. Szczepek M, et al. Among authors: sommer me. Nat Commun. 2014 Sep 10;5:4801. doi: 10.1038/ncomms5801. Nat Commun. 2014. PMID: 25205354 Free PMC article.
30 results