Somoza JR - Search Results

1

Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease.

Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. Wang SX, et al. Among authors: somoza jr. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11503-8. doi: 10.1073/pnas.0600489103. Epub 2006 Jul 24. Proc Natl Acad Sci U S A. 2006. PMID: 16864794 Free PMC article.

2

Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus.

Somoza JR, Chin MS, Focia PJ, Wang CC, Fletterick RJ. Somoza JR, et al. Biochemistry. 1996 Jun 4;35(22):7032-40. doi: 10.1021/bi953072p. Biochemistry. 1996. PMID: 8679528

3

Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex.

Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips JD, Hill CP, Fletterick RJ, Wang CC. Whitby FG, et al. Among authors: somoza jr. Biochemistry. 1997 Sep 2;36(35):10666-74. doi: 10.1021/bi9708850. Biochemistry. 1997. PMID: 9271497

4

Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan.

Somoza JR, Skillman AG Jr, Munagala NR, Oshiro CM, Knegtel RM, Mpoke S, Fletterick RJ, Kuntz ID, Wang CC. Somoza JR, et al. Biochemistry. 1998 Apr 21;37(16):5344-8. doi: 10.1021/bi973095z. Biochemistry. 1998. PMID: 9548915

5

Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.

Somoza JR, Skene RJ, Katz BA, Mol C, Ho JD, Jennings AJ, Luong C, Arvai A, Buggy JJ, Chi E, Tang J, Sang BC, Verner E, Wynands R, Leahy EM, Dougan DR, Snell G, Navre M, Knuth MW, Swanson RV, McRee DE, Tari LW. Somoza JR, et al. Structure. 2004 Jul;12(7):1325-34. doi: 10.1016/j.str.2004.04.012. Structure. 2004. PMID: 15242608 Free article.

6

Crystal structure of human cathepsin V.

Somoza JR, Zhan H, Bowman KK, Yu L, Mortara KD, Palmer JT, Clark JM, McGrath ME. Somoza JR, et al. Biochemistry. 2000 Oct 17;39(41):12543-51. doi: 10.1021/bi000951p. Biochemistry. 2000. PMID: 11027133

7

The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators.

Somoza JR, Palmer JT, Ho JD. Somoza JR, et al. J Mol Biol. 2002 Sep 20;322(3):559-68. doi: 10.1016/s0022-2836(02)00780-5. J Mol Biol. 2002. PMID: 12225749

8

The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.

Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K, Shrader WD, Sperandio D, Chan H, McGrath ME, Katz BA. Somoza JR, et al. Structure. 2003 Sep;11(9):1123-31. doi: 10.1016/s0969-2126(03)00148-5. Structure. 2003. PMID: 12962630 Free article.

9

Peptide ketobenzoxazole inhibitors bound to cathepsin K.

McGrath ME, Sprengeler PA, Hill CM, Martichonok V, Cheung H, Somoza JR, Palmer JT, Janc JW. McGrath ME, et al. Among authors: somoza jr. Biochemistry. 2003 Dec 30;42(51):15018-28. doi: 10.1021/bi035041x. Biochemistry. 2003. PMID: 14690410

10

Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).

Katz BA, Luong C, Ho JD, Somoza JR, Gjerstad E, Tang J, Williams SR, Verner E, Mackman RL, Young WB, Sprengeler PA, Chan H, Mortara K, Janc JW, McGrath ME. Katz BA, et al. Among authors: somoza jr. J Mol Biol. 2004 Nov 19;344(2):527-47. doi: 10.1016/j.jmb.2004.09.032. J Mol Biol. 2004. PMID: 15522303

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