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Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells.
Vacchini A, Chancellor A, Yang Q, Colombo R, Spagnuolo J, Berloffa G, Joss D, Øyås O, Lecchi C, De Simone G, Beshirova A, Nosi V, Loureiro JP, Morabito A, De Gregorio C, Pfeffer M, Schaefer V, Prota G, Zippelius A, Stelling J, Häussinger D, Brunelli L, Villalta P, Lepore M, Davoli E, Balbo S, Mori L, De Libero G. Vacchini A, et al. Among authors: spagnuolo j. Sci Immunol. 2024 May 10;9(95):eadn0126. doi: 10.1126/sciimmunol.adn0126. Epub 2024 May 10. Sci Immunol. 2024. PMID: 38728413
Surface protein and functional analyses identify CD4+CD39+ TCR αβ+ and activated TCR Vδ1+ cells with distinct pro-inflammatory functions in Crohn's disease lesions.
Devan J, Nosi V, Spagnuolo J, Chancellor A, Beshirova A, Loureiro JP, Vacchini A, Hendrik Niess J, Calogero R, Mori L, De Libero G, Hruz P. Devan J, et al. Among authors: spagnuolo j. Clin Exp Immunol. 2024 Jan 9;215(1):79-93. doi: 10.1093/cei/uxad098. Clin Exp Immunol. 2024. PMID: 37586415
Immunophenotypic characterization of TCR γδ T cells and MAIT cells in HIV-infected individuals developing Hodgkin's lymphoma.
Muller CKS, Spagnuolo J, Audigé A, Chancellor A, Russenberger D, Scherrer AU, Hoffmann M, Kouyos R, Battegay M, De Libero G, Speck RF; Swiss HIV Cohort Study. Muller CKS, et al. Among authors: spagnuolo j. Infect Agent Cancer. 2021 Apr 17;16(1):24. doi: 10.1186/s13027-021-00365-4. Infect Agent Cancer. 2021. PMID: 33865435 Free PMC article.
Interferon lambda 4 can directly activate human CD19+ B cells and CD8+ T cells.
Coto-Llerena M, Lepore M, Spagnuolo J, Di Blasi D, Calabrese D, Suslov A, Bantug G, Duong FH, Terracciano LM, De Libero G, Heim MH. Coto-Llerena M, et al. Among authors: spagnuolo j. Life Sci Alliance. 2020 Nov 6;4(1):e201900612. doi: 10.26508/lsa.201900612. Print 2021 Jan. Life Sci Alliance. 2020. PMID: 33158978 Free PMC article.
MR1-Restricted T Cells Are Unprecedented Cancer Fighters.
Vacchini A, Chancellor A, Spagnuolo J, Mori L, De Libero G. Vacchini A, et al. Among authors: spagnuolo j. Front Immunol. 2020 Apr 28;11:751. doi: 10.3389/fimmu.2020.00751. eCollection 2020. Front Immunol. 2020. PMID: 32411144 Free PMC article. Review.
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation.
Schmaler M, Colone A, Spagnuolo J, Zimmermann M, Lepore M, Kalinichenko A, Bhatia S, Cottier F, Rutishauser T, Pavelka N, Egli A, Azzali E, Pieroni M, Costantino G, Hruz P, Sauer U, Mori L, De Libero G. Schmaler M, et al. Among authors: spagnuolo j. Mucosal Immunol. 2018 Jul;11(4):1060-1070. doi: 10.1038/s41385-018-0020-9. Epub 2018 May 9. Mucosal Immunol. 2018. PMID: 29743612 Free article.
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