Spahr C - Search Results

1

A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys.

Stanislaus S, Hecht R, Yie J, Hager T, Hall M, Spahr C, Wang W, Weiszmann J, Li Y, Deng L, Winters D, Smith S, Zhou L, Li Y, Véniant MM, Xu J. Stanislaus S, et al. Among authors: spahr c. Endocrinology. 2017 May 1;158(5):1314-1327. doi: 10.1210/en.2016-1917. Endocrinology. 2017. PMID: 28324011

2

Ligand-binding mass spectrometry to study biotransformation of fusion protein drugs and guide immunoassay development: strategic approach and application to peptibodies targeting the thrombopoietin receptor.

Hall MP, Gegg C, Walker K, Spahr C, Ortiz R, Patel V, Yu S, Zhang L, Lu H, DeSilva B, Lee JW. Hall MP, et al. Among authors: spahr c. AAPS J. 2010 Dec;12(4):576-85. doi: 10.1208/s12248-010-9218-9. Epub 2010 Jul 13. AAPS J. 2010. PMID: 20625864 Free PMC article.

3

General LC-MS/MS method approach to quantify therapeutic monoclonal antibodies using a common whole antibody internal standard with application to preclinical studies.

Li H, Ortiz R, Tran L, Hall M, Spahr C, Walker K, Laudemann J, Miller S, Salimi-Moosavi H, Lee JW. Li H, et al. Among authors: spahr c. Anal Chem. 2012 Feb 7;84(3):1267-73. doi: 10.1021/ac202792n. Epub 2012 Jan 25. Anal Chem. 2012. PMID: 22243404

4

Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes.

Hecht R, Li YS, Sun J, Belouski E, Hall M, Hager T, Yie J, Wang W, Winters D, Smith S, Spahr C, Tam LT, Shen Z, Stanislaus S, Chinookoswong N, Lau Y, Sickmier A, Michaels ML, Boone T, Véniant MM, Xu J. Hecht R, et al. Among authors: spahr c. PLoS One. 2012;7(11):e49345. doi: 10.1371/journal.pone.0049345. Epub 2012 Nov 27. PLoS One. 2012. PMID: 23209571 Free PMC article.

5

Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities.

Hager T, Spahr C, Xu J, Salimi-Moosavi H, Hall M. Hager T, et al. Among authors: spahr c. Anal Chem. 2013 Mar 5;85(5):2731-8. doi: 10.1021/ac303203y. Epub 2013 Feb 19. Anal Chem. 2013. PMID: 23373459

6

Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies.

Mock M, Jacobitz AW, Langmead CJ, Sudom A, Yoo D, Humphreys SC, Alday M, Alekseychyk L, Angell N, Bi V, Catterall H, Chen CC, Chou HT, Conner KP, Cook KD, Correia AR, Dykstra A, Ghimire-Rijal S, Graham K, Grandsard P, Huh J, Hui JO, Jain M, Jann V, Jia L, Johnstone S, Khanal N, Kolvenbach C, Narhi L, Padaki R, Pelegri-O'Day EM, Qi W, Razinkov V, Rice AJ, Smith R, Spahr C, Stevens J, Sun Y, Thomas VA, van Driesche S, Vernon R, Wagner V, Walker KW, Wei Y, Winters D, Yang M, Campuzano IDG. Mock M, et al. Among authors: spahr c. MAbs. 2023 Jan-Dec;15(1):2256745. doi: 10.1080/19420862.2023.2256745. MAbs. 2023. PMID: 37698932 Free PMC article.

7

Recombinant human lecithin-cholesterol acyltransferase Fc fusion: analysis of N- and O-linked glycans and identification and elimination of a xylose-based O-linked tetrasaccharide core in the linker region.

Spahr C, Kim JJ, Deng S, Kodama P, Xia Z, Tang J, Zhang R, Siu S, Nuanmanee N, Estes B, Stevens J, Zhou M, Lu HS. Spahr C, et al. Protein Sci. 2013 Dec;22(12):1739-53. doi: 10.1002/pro.2373. Protein Sci. 2013. PMID: 24115046 Free PMC article.

8

O-glycosylation of glycine-serine linkers in recombinant Fc-fusion proteins: attachment of glycosaminoglycans and other intermediates with phosphorylation at the xylose sugar subunit.

Spahr C, Shi SD, Lu HS. Spahr C, et al. MAbs. 2014 Jul-Aug;6(4):904-14. doi: 10.4161/mabs.28763. MAbs. 2014. PMID: 24927272 Free PMC article.

9

High-resolution mass spectrometry confirms the presence of a hydroxyproline (Hyp) post-translational modification in the GGGGP linker of an Fc-fusion protein.

Spahr C, Gunasekaran K, Walker KW, Shi SD. Spahr C, et al. MAbs. 2017 Jul;9(5):812-819. doi: 10.1080/19420862.2017.1325556. Epub 2017 May 16. MAbs. 2017. PMID: 28506197 Free PMC article.

10

Discovery, characterization, and remediation of a C-terminal Fc-extension in proteins expressed in CHO cells.

Spahr CS, Daris ME, Graham KC, Soriano BD, Stevens JL, Shi SD. Spahr CS, et al. MAbs. 2018 Nov-Dec;10(8):1291-1300. doi: 10.1080/19420862.2018.1511197. Epub 2018 Sep 20. MAbs. 2018. PMID: 30148415 Free PMC article.

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