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Structural Evidence of a Major Conformational Change Triggered by Substrate Binding in DapE Enzymes: Impact on the Catalytic Mechanism.
Biochemistry. 2018 Feb 6;57(5):574-584. doi: 10.1021/acs.biochem.7b01151. Epub 2018 Jan 12.
Biochemistry. 2018.
PMID: 29272107
Free PMC article.
The dimerization domain in DapE enzymes is required for catalysis.
Nocek B, Starus A, Makowska-Grzyska M, Gutierrez B, Sanchez S, Jedrzejczak R, Mack JC, Olsen KW, Joachimiak A, Holz RC.
Nocek B, et al. Among authors: starus a.
PLoS One. 2014 May 7;9(5):e93593. doi: 10.1371/journal.pone.0093593. eCollection 2014.
PLoS One. 2014.
PMID: 24806882
Free PMC article.
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Inhibition of the dapE-Encoded N-Succinyl-L,L-diaminopimelic Acid Desuccinylase from Neisseria meningitidis by L-Captopril.
Starus A, Nocek B, Bennett B, Larrabee JA, Shaw DL, Sae-Lee W, Russo MT, Gillner DM, Makowska-Grzyska M, Joachimiak A, Holz RC.
Starus A, et al.
Biochemistry. 2015 Aug 11;54(31):4834-44. doi: 10.1021/acs.biochem.5b00475. Epub 2015 Aug 3.
Biochemistry. 2015.
PMID: 26186504
Free PMC article.
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Indoline-6-Sulfonamide Inhibitors of the Bacterial Enzyme DapE.
Reidl CT, Heath TK, Darwish I, Torrez RM, Moore M, Gild E, Nocek BP, Starus A, Holz RC, Becker DP.
Reidl CT, et al. Among authors: starus a.
Antibiotics (Basel). 2020 Sep 11;9(9):595. doi: 10.3390/antibiotics9090595.
Antibiotics (Basel). 2020.
PMID: 32933028
Free PMC article.
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Tetrazole-based inhibitors of the bacterial enzyme N-succinyl-l,l-2,6-diaminopimelic acid desuccinylase as potential antibiotics.
DiPuma T Jr, Thabthimthong T, Kelley EH, Konczak K, Beulke M, Herbert C, S Habeeb Mohammad T, Starus A, Nocek B, Olsen KW, Holz RC, Becker DP.
DiPuma T Jr, et al. Among authors: starus a.
Bioorg Med Chem Lett. 2023 Mar 1;83:129177. doi: 10.1016/j.bmcl.2023.129177. Epub 2023 Feb 9.
Bioorg Med Chem Lett. 2023.
PMID: 36764468
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Clearance of ctDNA in triple-negative and HER2-positive breast cancer patients during neoadjuvant treatment is correlated with pathologic complete response.
Ciriaco N, Zamora E, Escrivá-de-Romaní S, Miranda Gómez I, Jiménez Flores J, Saura C, Sloane H, Starus A, Fredebohm J, Georgieva L, Speight G, Jones F, Ramón Y Cajal S, Espinosa-Bravo M, Peg V.
Ciriaco N, et al. Among authors: starus a.
Ther Adv Med Oncol. 2022 Nov 29;14:17588359221139601. doi: 10.1177/17588359221139601. eCollection 2022.
Ther Adv Med Oncol. 2022.
PMID: 36479470
Free PMC article.
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