Steiner H - Search Results

1

Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation.

Trambauer J, Rodríguez Sarmiento RM, Fukumori A, Feederle R, Baumann K, Steiner H. Trambauer J, et al. Among authors: steiner h. EMBO Rep. 2020 Jan 7;21(1):e47996. doi: 10.15252/embr.201947996. Epub 2019 Nov 25. EMBO Rep. 2020. PMID: 31762188 Free PMC article.

2

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch.

Sastre M, Steiner H, Fuchs K, Capell A, Multhaup G, Condron MM, Teplow DB, Haass C. Sastre M, et al. Among authors: steiner h. EMBO Rep. 2001 Sep;2(9):835-41. doi: 10.1093/embo-reports/kve180. Epub 2001 Aug 23. EMBO Rep. 2001. PMID: 11520861 Free PMC article.

3

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish.

Geling A, Steiner H, Willem M, Bally-Cuif L, Haass C. Geling A, et al. Among authors: steiner h. EMBO Rep. 2002 Jul;3(7):688-94. doi: 10.1093/embo-reports/kvf124. EMBO Rep. 2002. PMID: 12101103 Free PMC article.

4

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Okochi M, et al. Among authors: steiner h. EMBO J. 2002 Oct 15;21(20):5408-16. doi: 10.1093/emboj/cdf541. EMBO J. 2002. PMID: 12374741 Free PMC article.

5

Reconstitution of gamma-secretase activity.

Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C. Edbauer D, et al. Among authors: steiner h. Nat Cell Biol. 2003 May;5(5):486-8. doi: 10.1038/ncb960. Nat Cell Biol. 2003. PMID: 12679784

6

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.

Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C. Kaether C, et al. Among authors: steiner h. EMBO J. 2004 Dec 8;23(24):4738-48. doi: 10.1038/sj.emboj.7600478. Epub 2004 Nov 18. EMBO J. 2004. PMID: 15549135 Free PMC article.

7

Uncovering gamma-secretase.

Steiner H. Steiner H. Curr Alzheimer Res. 2004 Aug;1(3):175-81. doi: 10.2174/1567205043332081. Curr Alzheimer Res. 2004. PMID: 15975065 Review.

8

Secretion of the Notch-1 Abeta-like peptide during Notch signaling.

Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M. Okochi M, et al. Among authors: steiner h. J Biol Chem. 2006 Mar 24;281(12):7890-8. doi: 10.1074/jbc.M513250200. Epub 2006 Jan 23. J Biol Chem. 2006. PMID: 16434391 Free article.

9

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H. Yamasaki A, et al. Among authors: steiner h. J Neurosci. 2006 Apr 5;26(14):3821-8. doi: 10.1523/JNEUROSCI.5354-05.2006. J Neurosci. 2006. PMID: 16597736 Free PMC article.

10

N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase.

Narlawar R, Pérez Revuelta BI, Baumann K, Schubenel R, Haass C, Steiner H, Schmidt B. Narlawar R, et al. Among authors: steiner h. Bioorg Med Chem Lett. 2007 Jan 1;17(1):176-82. doi: 10.1016/j.bmcl.2006.09.061. Epub 2006 Oct 10. Bioorg Med Chem Lett. 2007. PMID: 17035010

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