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2016 1
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2019 7
2020 2
2021 3
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2023 7
2024 3

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24 results

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Page 1
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. Nature. 2023. PMID: 37821702 Free PMC article.
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.
Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D. Ogrodnik M, et al. Among authors: victorelli s. Cell Metab. 2019 May 7;29(5):1061-1077.e8. doi: 10.1016/j.cmet.2018.12.008. Epub 2019 Jan 3. Cell Metab. 2019. PMID: 30612898 Free PMC article.
Cytoplasmic DNA: sources, sensing, and role in aging and disease.
Miller KN, Victorelli SG, Salmonowicz H, Dasgupta N, Liu T, Passos JF, Adams PD. Miller KN, et al. Among authors: victorelli sg. Cell. 2021 Oct 28;184(22):5506-5526. doi: 10.1016/j.cell.2021.09.034. Cell. 2021. PMID: 34715021 Free PMC article. Review.
Spatial mapping of cellular senescence: emerging challenges and opportunities.
Gurkar AU, Gerencser AA, Mora AL, Nelson AC, Zhang AR, Lagnado AB, Enninful A, Benz C, Furman D, Beaulieu D, Jurk D, Thompson EL, Wu F, Rodriguez F, Barthel G, Chen H, Phatnani H, Heckenbach I, Chuang JH, Horrell J, Petrescu J, Alder JK, Lee JH, Niedernhofer LJ, Kumar M, Königshoff M, Bueno M, Sokka M, Scheibye-Knudsen M, Neretti N, Eickelberg O, Adams PD, Hu Q, Zhu Q, Porritt RA, Dong R, Peters S, Victorelli S, Pengo T, Khaliullin T, Suryadevara V, Fu X, Bar-Joseph Z, Ji Z, Passos JF. Gurkar AU, et al. Among authors: victorelli s. Nat Aging. 2023 Jul;3(7):776-790. doi: 10.1038/s43587-023-00446-6. Epub 2023 Jul 3. Nat Aging. 2023. PMID: 37400722 Free PMC article. Review.
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.
Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF. Anderson R, et al. Among authors: victorelli s. EMBO J. 2019 Mar 1;38(5):e100492. doi: 10.15252/embj.2018100492. Epub 2019 Feb 8. EMBO J. 2019. PMID: 30737259 Free PMC article.
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Zhu Y, Tchkonia T, Kirkland JL. Hickson LJ, et al. Among authors: victorelli sg. EBioMedicine. 2019 Sep;47:446-456. doi: 10.1016/j.ebiom.2019.08.069. Epub 2019 Sep 18. EBioMedicine. 2019. PMID: 31542391 Free PMC article.
Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction.
Victorelli S, Lagnado A, Halim J, Moore W, Talbot D, Barrett K, Chapman J, Birch J, Ogrodnik M, Meves A, Pawlikowski JS, Jurk D, Adams PD, van Heemst D, Beekman M, Slagboom PE, Gunn DA, Passos JF. Victorelli S, et al. EMBO J. 2019 Dec 2;38(23):e101982. doi: 10.15252/embj.2019101982. Epub 2019 Oct 21. EMBO J. 2019. PMID: 31633821 Free PMC article.
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.
Lagnado A, Leslie J, Ruchaud-Sparagano MH, Victorelli S, Hirsova P, Ogrodnik M, Collins AL, Vizioli MG, Habiballa L, Saretzki G, Evans SA, Salmonowicz H, Hruby A, Geh D, Pavelko KD, Dolan D, Reeves HL, Grellscheid S, Wilson CH, Pandanaboyana S, Doolittle M, von Zglinicki T, Oakley F, Gallage S, Wilson CL, Birch J, Carroll B, Chapman J, Heikenwalder M, Neretti N, Khosla S, Masuda CA, Tchkonia T, Kirkland JL, Jurk D, Mann DA, Passos JF. Lagnado A, et al. Among authors: victorelli s. EMBO J. 2021 May 3;40(9):e106048. doi: 10.15252/embj.2020106048. Epub 2021 Mar 25. EMBO J. 2021. PMID: 33764576 Free PMC article.
Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice.
Ogrodnik M, Evans SA, Fielder E, Victorelli S, Kruger P, Salmonowicz H, Weigand BM, Patel AD, Pirtskhalava T, Inman CL, Johnson KO, Dickinson SL, Rocha A, Schafer MJ, Zhu Y, Allison DB, von Zglinicki T, LeBrasseur NK, Tchkonia T, Neretti N, Passos JF, Kirkland JL, Jurk D. Ogrodnik M, et al. Among authors: victorelli s. Aging Cell. 2021 Feb;20(2):e13296. doi: 10.1111/acel.13296. Epub 2021 Jan 20. Aging Cell. 2021. PMID: 33470505 Free PMC article.
COPIng with senescence.
Victorelli S, Passos JF. Victorelli S, et al. Nat Cell Biol. 2023 Dec;25(12):1724-1725. doi: 10.1038/s41556-023-01276-9. Nat Cell Biol. 2023. PMID: 38012404 No abstract available.
24 results