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Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart.
Walejko JM, Christopher BA, Crown SB, Zhang GF, Pickar-Oliver A, Yoneshiro T, Foster MW, Page S, van Vliet S, Ilkayeva O, Muehlbauer MJ, Carson MW, Brozinick JT, Hammond CD, Gimeno RE, Moseley MA, Kajimura S, Gersbach CA, Newgard CB, White PJ, McGarrah RW. Walejko JM, et al. Among authors: page s. Nat Commun. 2021 Mar 15;12(1):1680. doi: 10.1038/s41467-021-21962-2. Nat Commun. 2021. PMID: 33723250 Free PMC article.
Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats.
McGarrah RW, Zhang GF, Christopher BA, Deleye Y, Walejko JM, Page S, Ilkayeva O, White PJ, Newgard CB. McGarrah RW, et al. Among authors: page s. Am J Physiol Endocrinol Metab. 2020 Feb 1;318(2):E216-E223. doi: 10.1152/ajpendo.00334.2019. Epub 2019 Dec 3. Am J Physiol Endocrinol Metab. 2020. PMID: 31794262 Free PMC article.