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Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells.
Hernández-López P, van Diest E, Brazda P, Heijhuurs S, Meringa A, Hoorens van Heyningen L, Riillo C, Schwenzel C, Zintchenko M, Johanna I, Nicolasen MJT, Cleven A, Kluiver TA, Millen R, Zheng J, Karaiskaki F, Straetemans T, Clevers H, de Bree R, Stunnenberg HG, Peng WC, Roodhart J, Minguet S, Sebestyén Z, Beringer DX, Kuball J. Hernández-López P, et al. Among authors: straetemans t. Nat Immunol. 2024 Jan;25(1):88-101. doi: 10.1038/s41590-023-01665-0. Epub 2023 Nov 27. Nat Immunol. 2024. PMID: 38012415
Uncovering the mode of action of engineered T cells in patient cancer organoids.
Dekkers JF, Alieva M, Cleven A, Keramati F, Wezenaar AKL, van Vliet EJ, Puschhof J, Brazda P, Johanna I, Meringa AD, Rebel HG, Buchholz MB, Barrera Román M, Zeeman AL, de Blank S, Fasci D, Geurts MH, Cornel AM, Driehuis E, Millen R, Straetemans T, Nicolasen MJT, Aarts-Riemens T, Ariese HCR, Johnson HR, van Ineveld RL, Karaiskaki F, Kopper O, Bar-Ephraim YE, Kretzschmar K, Eggermont AMM, Nierkens S, Wehrens EJ, Stunnenberg HG, Clevers H, Kuball J, Sebestyen Z, Rios AC. Dekkers JF, et al. Among authors: straetemans t. Nat Biotechnol. 2023 Jan;41(1):60-69. doi: 10.1038/s41587-022-01397-w. Epub 2022 Jul 25. Nat Biotechnol. 2023. PMID: 35879361 Free PMC article.
Untouched GMP-Ready Purified Engineered Immune Cells to Treat Cancer.
Straetemans T, Gründer C, Heijhuurs S, Hol S, Slaper-Cortenbach I, Bönig H, Sebestyen Z, Kuball J. Straetemans T, et al. Clin Cancer Res. 2015 Sep 1;21(17):3957-68. doi: 10.1158/1078-0432.CCR-14-2860. Epub 2015 May 19. Clin Cancer Res. 2015. PMID: 25991821
GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR.
Straetemans T, Kierkels GJJ, Doorn R, Jansen K, Heijhuurs S, Dos Santos JM, van Muyden ADD, Vie H, Clemenceau B, Raymakers R, de Witte M, Sebestyén Z, Kuball J. Straetemans T, et al. Front Immunol. 2018 May 30;9:1062. doi: 10.3389/fimmu.2018.01062. eCollection 2018. Front Immunol. 2018. PMID: 29899740 Free PMC article.
Adding Help to an HLA-A*24:02 Tumor-Reactive γδTCR Increases Tumor Control.
Johanna I, Hernández-López P, Heijhuurs S, Scheper W, Bongiovanni L, de Bruin A, Beringer DX, Oostvogels R, Straetemans T, Sebestyen Z, Kuball J. Johanna I, et al. Among authors: straetemans t. Front Immunol. 2021 Oct 25;12:752699. doi: 10.3389/fimmu.2021.752699. eCollection 2021. Front Immunol. 2021. PMID: 34759930 Free PMC article.
γδ T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity.
Janssen A, Villacorta Hidalgo J, Beringer DX, van Dooremalen S, Fernando F, van Diest E, Terrizi AR, Bronsert P, Kock S, Schmitt-Gräff A, Werner M, Heise K, Follo M, Straetemans T, Sebestyen Z, Chudakov DM, Kasatskaya SA, Frenkel FE, Ravens S, Spierings E, Prinz I, Küppers R, Malkovsky M, Fisch P, Kuball J. Janssen A, et al. Among authors: straetemans t. Cancer Immunol Res. 2020 Apr;8(4):530-543. doi: 10.1158/2326-6066.CIR-19-0513. Epub 2020 Feb 4. Cancer Immunol Res. 2020. PMID: 32019779
Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds.
van Diest E, Hernández López P, Meringa AD, Vyborova A, Karaiskaki F, Heijhuurs S, Gumathi Bormin J, van Dooremalen S, Nicolasen MJT, Gatti LCDE, Johanna I, Straetemans T, Sebestyén Z, Beringer DX, Kuball J. van Diest E, et al. Among authors: straetemans t. J Immunother Cancer. 2021 Nov;9(11):e003850. doi: 10.1136/jitc-2021-003850. J Immunother Cancer. 2021. PMID: 34815357 Free PMC article.
29 results