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Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway.
Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2120403119. doi: 10.1073/pnas.2120403119. Epub 2022 Mar 31.
Proc Natl Acad Sci U S A. 2022.
PMID: 35357972
Free PMC article.
Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly.
Stransky LA, Forgac M.
Stransky LA, et al.
J Biol Chem. 2015 Nov 6;290(45):27360-27369. doi: 10.1074/jbc.M115.659128. Epub 2015 Sep 16.
J Biol Chem. 2015.
PMID: 26378229
Free PMC article.
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HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species.
Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG Jr.
Nicholson HE, et al. Among authors: stransky la.
Sci Signal. 2019 Oct 1;12(601):eaay0482. doi: 10.1126/scisignal.aay0482.
Sci Signal. 2019.
PMID: 31575731
Free PMC article.
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AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells.
Collins MP, Stransky LA, Forgac M.
Collins MP, et al. Among authors: stransky la.
J Biol Chem. 2020 Jul 10;295(28):9433-9444. doi: 10.1074/jbc.RA120.013223. Epub 2020 May 14.
J Biol Chem. 2020.
PMID: 32409581
Free PMC article.
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