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Intracellular Staphylococcus aureus triggers pyroptosis and contributes to inhibition of healing due to perforin-2 suppression.
Pastar I, Sawaya AP, Marjanovic J, Burgess JL, Strbo N, Rivas KE, Wikramanayake TC, Head CR, Stone RC, Jozic I, Stojadinovic O, Kornfeld EY, Kirsner RS, Lev-Tov H, Tomic-Canic M. Pastar I, et al. Among authors: strbo n. J Clin Invest. 2021 Dec 15;131(24):e133727. doi: 10.1172/JCI133727. J Clin Invest. 2021. PMID: 34730110 Free PMC article.
Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria.
McCormack RM, de Armas LR, Shiratsuchi M, Fiorentino DG, Olsson ML, Lichtenheld MG, Morales A, Lyapichev K, Gonzalez LE, Strbo N, Sukumar N, Stojadinovic O, Plano GV, Munson GP, Tomic-Canic M, Kirsner RS, Russell DG, Podack ER. McCormack RM, et al. Among authors: strbo n. Elife. 2015 Sep 24;4:e06508. doi: 10.7554/eLife.06508. Elife. 2015. PMID: 26402460 Free PMC article.
Single cell analyses reveal specific distribution of anti-bacterial molecule Perforin-2 in human skin and its modulation by wounding and Staphylococcus aureus infection.
Strbo N, Pastar I, Romero L, Chen V, Vujanac M, Sawaya AP, Jozic I, Ferreira ADF, Wong LL, Head C, Stojadinovic O, Garcia D, O'Neill K, Drakulich S, Taller S, Kirsner RS, Tomic-Canic M. Strbo N, et al. Exp Dermatol. 2019 Mar;28(3):225-232. doi: 10.1111/exd.13870. Epub 2019 Feb 12. Exp Dermatol. 2019. PMID: 30609079 Free PMC article.
A tractable, simplified ex vivo human skin model of wound infection.
Yoon DJ, Fregoso DR, Nguyen D, Chen V, Strbo N, Fuentes JJ, Tomic-Canic M, Crawford R, Pastar I, Isseroff RR. Yoon DJ, et al. Among authors: strbo n. Wound Repair Regen. 2019 Jul;27(4):421-425. doi: 10.1111/wrr.12712. Epub 2019 Mar 26. Wound Repair Regen. 2019. PMID: 30825247 Free PMC article.
Impaired B Cell Function in Mice Lacking Perforin-2.
Frasca D, Diaz A, Romero M, Vazquez T, Strbo N, Romero L, McCormack RM, Podack ER, Blomberg BB. Frasca D, et al. Among authors: strbo n. Front Immunol. 2020 Feb 27;11:328. doi: 10.3389/fimmu.2020.00328. eCollection 2020. Front Immunol. 2020. PMID: 32180773 Free PMC article.
Skin Microbiota and its Interplay with Wound Healing.
Tomic-Canic M, Burgess JL, O'Neill KE, Strbo N, Pastar I. Tomic-Canic M, et al. Among authors: strbo n. Am J Clin Dermatol. 2020 Sep;21(Suppl 1):36-43. doi: 10.1007/s40257-020-00536-w. Am J Clin Dermatol. 2020. PMID: 32914215 Free PMC article. Review.
Perforins Expression by Cutaneous Gamma Delta T Cells.
O'Neill K, Pastar I, Tomic-Canic M, Strbo N. O'Neill K, et al. Among authors: strbo n. Front Immunol. 2020 Aug 14;11:1839. doi: 10.3389/fimmu.2020.01839. eCollection 2020. Front Immunol. 2020. PMID: 32922397 Free PMC article. Review.
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