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Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies.
Tarpley M, Oladapo HO, Strepay D, Caligan TB, Chdid L, Shehata H, Roques JR, Thomas R, Laudeman CP, Onyenwoke RU, Darr DB, Williams KP. Tarpley M, et al. Among authors: strepay d. Eur J Pharm Sci. 2021 Jul 1;162:105821. doi: 10.1016/j.ejps.2021.105821. Epub 2021 Mar 27. Eur J Pharm Sci. 2021. PMID: 33781856 Free PMC article.
Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.
Oladapo HO, Tarpley M, Sauer SJ, Addo KA, Ingram SM, Strepay D, Ehe BK, Chdid L, Trinkler M, Roques JR, Darr DB, Fleming JM, Devi GR, Williams KP. Oladapo HO, et al. Among authors: strepay d. Cancer Lett. 2017 Dec 28;411:136-149. doi: 10.1016/j.canlet.2017.09.033. Epub 2017 Sep 28. Cancer Lett. 2017. PMID: 28965853 Free PMC article.