Stubenrauch K - Search Results

1

Subset analysis of patients experiencing clinical events of a potentially immunogenic nature in the pivotal clinical trials of tocilizumab for rheumatoid arthritis: Evaluation of an antidrug antibody ELISA using clinical adverse event-driven immunogenicity testing.

Stubenrauch K, Wessels U, Birnboeck H, Ramirez F, Jahreis A, Schleypen J. Stubenrauch K, et al. Clin Ther. 2010 Aug;32(9):1597-609. doi: 10.1016/j.clinthera.2010.07.021. Clin Ther. 2010. PMID: 20974317

2

Evaluation of an immunoassay for human-specific quantitation of therapeutic antibodies in serum samples from non-human primates.

Stubenrauch K, Wessels U, Lenz H. Stubenrauch K, et al. J Pharm Biomed Anal. 2009 May 1;49(4):1003-8. doi: 10.1016/j.jpba.2009.01.030. Epub 2009 Feb 5. J Pharm Biomed Anal. 2009. PMID: 19250787

3

Evaluation of a biosensor immunoassay for simultaneous characterization of isotype and binding region of human anti-tocilizumab antibodies with control by surrogate standards.

Stubenrauch K, Wessels U, Vogel R, Schleypen J. Stubenrauch K, et al. Anal Biochem. 2009 Jul 15;390(2):189-96. doi: 10.1016/j.ab.2009.04.021. Epub 2009 Apr 18. Anal Biochem. 2009. PMID: 19379704

4

Impact of molecular processing in the hinge region of therapeutic IgG4 antibodies on disposition profiles in cynomolgus monkeys.

Stubenrauch K, Wessels U, Regula JT, Kettenberger H, Schleypen J, Kohnert U. Stubenrauch K, et al. Drug Metab Dispos. 2010 Jan;38(1):84-91. doi: 10.1124/dmd.109.029751. Drug Metab Dispos. 2010. PMID: 19850673

5

Evaluation of a generic immunoassay with drug tolerance to detect immune complexes in serum samples from cynomolgus monkeys after administration of human antibodies.

Stubenrauch K, Wessels U, Essig U, Vogel R, Schleypen J. Stubenrauch K, et al. J Pharm Biomed Anal. 2010 Jun 5;52(2):249-54. doi: 10.1016/j.jpba.2009.12.029. Epub 2010 Jan 4. J Pharm Biomed Anal. 2010. PMID: 20083366

6

Quality requirements for critical assay reagents used in bioanalysis of therapeutic proteins: what bioanalysts should know about their reagents.

Staack RF, Stracke JO, Stubenrauch K, Vogel R, Schleypen J, Papadimitriou A. Staack RF, et al. Among authors: stubenrauch k. Bioanalysis. 2011 Mar;3(5):523-34. doi: 10.4155/bio.11.16. Bioanalysis. 2011. PMID: 21388265 Review.

7

Generic anti-drug antibody assay with drug tolerance in serum samples from mice exposed to human antibodies.

Stubenrauch K, Mackeben K, Vogel R, Heinrich J. Stubenrauch K, et al. Anal Biochem. 2012 Nov 15;430(2):193-9. doi: 10.1016/j.ab.2012.08.022. Epub 2012 Aug 27. Anal Biochem. 2012. PMID: 22935295

8

Characterization of murine anti-human Fab antibodies for use in an immunoassay for generic quantification of human Fab fragments in non-human serum samples including cynomolgus monkey samples.

Stubenrauch K, Wessels U, Essig U, Kowalewsky F, Vogel R, Heinrich J. Stubenrauch K, et al. J Pharm Biomed Anal. 2013 Jan;72:208-15. doi: 10.1016/j.jpba.2012.08.023. Epub 2012 Sep 7. J Pharm Biomed Anal. 2013. PMID: 23017233

9

An immunodepletion procedure advances free angiopoietin-2 determination in human plasma samples during anti-cancer therapy with bispecific anti-Ang2/VEGF CrossMab.

Stubenrauch K, Wessels U, Essig U, Vogel R, Waltenberger H, Hansbauer A, Koehler A, Heinrich J. Stubenrauch K, et al. J Pharm Biomed Anal. 2015 Jan;102:459-67. doi: 10.1016/j.jpba.2014.10.005. Epub 2014 Oct 14. J Pharm Biomed Anal. 2015. PMID: 25459946

10

Detection of antidrug antibodies against human therapeutic antibodies lacking Fc-effector functions by usage of soluble Fcγ receptor I.

Wessels U, Poehler A, Moheysen-Zadeh M, Zadak M, Staack RF, Umana P, Heinrich J, Stubenrauch K. Wessels U, et al. Among authors: stubenrauch k. Bioanalysis. 2016 Oct;8(20):2135-45. doi: 10.4155/bio-2016-0182. Epub 2016 Sep 1. Bioanalysis. 2016. PMID: 27582032 Free article.

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