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Twice-daily dosing of esomeprazole effectively inhibits acid secretion in CYP2C19 rapid metabolisers compared with twice-daily omeprazole, rabeprazole or lansoprazole.
Sahara S, Sugimoto M, Uotani T, Ichikawa H, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Umemura K, Miyajima H, Furuta T. Sahara S, et al. Among authors: sugimoto m, sugimoto k. Aliment Pharmacol Ther. 2013 Nov;38(9):1129-37. doi: 10.1111/apt.12492. Epub 2013 Sep 16. Aliment Pharmacol Ther. 2013. PMID: 24099474 Free article. Clinical Trial.
Rabeprazole 10 mg q.d.s. decreases 24-h intragastric acidity significantly more than rabeprazole 20 mg b.d. or 40 mg o.m., overcoming CYP2C19 genotype.
Sugimoto M, Shirai N, Nishino M, Kodaira C, Uotani T, Yamade M, Sahara S, Ichikawa H, Sugimoto K, Miyajima H, Furuta T. Sugimoto M, et al. Among authors: sugimoto k. Aliment Pharmacol Ther. 2012 Oct;36(7):627-34. doi: 10.1111/apt.12014. Epub 2012 Aug 10. Aliment Pharmacol Ther. 2012. PMID: 22882464 Free article.
3,392 results