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Inhibition of aquaporin-3 water channel in the colon induces diarrhea.
Ikarashi N, Kon R, Iizasa T, Suzuki N, Hiruma R, Suenaga K, Toda T, Ishii M, Hoshino M, Ochiai W, Sugiyama K. Ikarashi N, et al. Among authors: sugiyama k. Biol Pharm Bull. 2012;35(6):957-62. doi: 10.1248/bpb.35.957. Biol Pharm Bull. 2012. PMID: 22687538 Free article.
Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract.
Kon R, Ikarashi N, Nagoya C, Takayama T, Kusunoki Y, Ishii M, Ueda H, Ochiai W, Machida Y, Sugita K, Sugiyama K. Kon R, et al. Among authors: sugiyama k. J Ethnopharmacol. 2014 Feb 27;152(1):190-200. doi: 10.1016/j.jep.2013.12.055. Epub 2014 Jan 8. J Ethnopharmacol. 2014. PMID: 24412547
Relationship between Aging-Related Skin Dryness and Aquaporins.
Ikarashi N, Kon R, Kaneko M, Mizukami N, Kusunoki Y, Sugiyama K. Ikarashi N, et al. Among authors: sugiyama k. Int J Mol Sci. 2017 Jul 18;18(7):1559. doi: 10.3390/ijms18071559. Int J Mol Sci. 2017. PMID: 28718791 Free PMC article.
2,444 results