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Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid-beta and cholesterol homeostasis in blood-brain barrier endothelial cells.
Fanaee-Danesh E, Gali CC, Tadic J, Zandl-Lang M, Carmen Kober A, Agujetas VR, de Dios C, Tam-Amersdorfer C, Stracke A, Albrecher NM, Manavalan APC, Reiter M, Sun Y, Colell A, Madeo F, Malle E, Panzenboeck U. Fanaee-Danesh E, et al. Among authors: sun y. Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2224-2245. doi: 10.1016/j.bbadis.2019.04.019. Epub 2019 May 2. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31055081 Free article.
Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells.
Zandl-Lang M, Fanaee-Danesh E, Sun Y, Albrecher NM, Gali CC, Čančar I, Kober A, Tam-Amersdorfer C, Stracke A, Storck SM, Saeed A, Stefulj J, Pietrzik CU, Wilson MR, Björkhem I, Panzenboeck U. Zandl-Lang M, et al. Among authors: sun y. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jan;1863(1):40-60. doi: 10.1016/j.bbalip.2017.09.008. Epub 2017 Sep 20. Biochim Biophys Acta Mol Cell Biol Lipids. 2018. PMID: 28941799
Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice.
Gali CC, Fanaee-Danesh E, Zandl-Lang M, Albrecher NM, Tam-Amersdorfer C, Stracke A, Sachdev V, Reichmann F, Sun Y, Avdili A, Reiter M, Kratky D, Holzer P, Lass A, Kandimalla KK, Panzenboeck U. Gali CC, et al. Among authors: sun y. Mol Cell Neurosci. 2019 Sep;99:103390. doi: 10.1016/j.mcn.2019.103390. Epub 2019 Jul 2. Mol Cell Neurosci. 2019. PMID: 31276749 Free PMC article.
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