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Page 1
Discovery of lipophilic two-pore channel agonists.
Gerndt S, Krogsaeter E, Patel S, Bracher F, Grimm C. Gerndt S, et al. FEBS J. 2020 Dec;287(24):5284-5293. doi: 10.1111/febs.15432. Epub 2020 Jun 14. FEBS J. 2020. PMID: 32478984 Free article. Review.
The lysosomotrope GPN mobilises Ca2+ from acidic organelles.
Yuan Y, Kilpatrick BS, Gerndt S, Bracher F, Grimm C, Schapira AH, Patel S. Yuan Y, et al. Among authors: gerndt s. J Cell Sci. 2021 Mar 11;134(6):jcs256578. doi: 10.1242/jcs.256578. J Cell Sci. 2021. PMID: 33602742 Free PMC article.
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
Gerndt S, Chen CC, Chao YK, Yuan Y, Burgstaller S, Scotto Rosato A, Krogsaeter E, Urban N, Jacob K, Nguyen ONP, Miller MT, Keller M, Vollmar AM, Gudermann T, Zierler S, Schredelseker J, Schaefer M, Biel M, Malli R, Wahl-Schott C, Bracher F, Patel S, Grimm C. Gerndt S, et al. Elife. 2020 Mar 16;9:e54712. doi: 10.7554/eLife.54712. Elife. 2020. PMID: 32167471 Free PMC article.
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth.
Müller M, Gerndt S, Chao YK, Zisis T, Nguyen ONP, Gerwien A, Urban N, Müller C, Gegenfurtner FA, Geisslinger F, Ortler C, Chen CC, Zahler S, Biel M, Schaefer M, Grimm C, Bracher F, Vollmar AM, Bartel K. Müller M, et al. Among authors: gerndt s. Cell Chem Biol. 2021 Aug 19;28(8):1119-1131.e27. doi: 10.1016/j.chembiol.2021.01.023. Epub 2021 Feb 23. Cell Chem Biol. 2021. PMID: 33626324 Free article.