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6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro.
Swaim CD, Dwivedi V, Perng YC, Zhao X, Canadeo LA, Harastani HH, Darling TL, Boon ACM, Lenschow DJ, Kulkarni V, Huibregtse JM. Swaim CD, et al. iScience. 2021 Oct 22;24(10):103213. doi: 10.1016/j.isci.2021.103213. Epub 2021 Oct 2. iScience. 2021. PMID: 34632326 Free PMC article.
SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity.
Leyva-Illades D, Chen P, Zogzas CE, Hutchens S, Mercado JM, Swaim CD, Morrisett RA, Bowman AB, Aschner M, Mukhopadhyay S. Leyva-Illades D, et al. Among authors: swaim cd. J Neurosci. 2014 Oct 15;34(42):14079-95. doi: 10.1523/JNEUROSCI.2329-14.2014. J Neurosci. 2014. PMID: 25319704 Free PMC article.